Copper-Catalyzed Oxidative Three-Component Synthesis of N, N′, N"-Trisubstituted Guanidines

被引：48
|
作者：
Li, Jihui [1 ]
Neuville, Luc [1 ]
机构：
[1] CNRS, Inst Chim Subst Nat, Ctr Rech Gif, Lab Int Associe, F-91198 Gif Sur Yvette, France
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 24期
关键词：
PALLADIUM(II)-CATALYZED SYNTHESIS; EFFICIENT SYNTHESIS; BOND FORMATION; C-N; PALLADIUM; AMIDINES; ARYLATION; ARYL; CYANAMIDE; GUANIDINYLATION;
D O I：
10.1021/ol4029622
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed three-component synthesis of trisubstituted N-aryl guanidines involving cyanamides, arylboronic acids, and amines has been developed. This operationally simple oxidative process, which is performed in the presence of K2CO3, a catalytic amount of CuCl2 center dot 2H(2)O, bipyridine, and oxygen (1 atm), allows the rapid assembly of N,N',N ''-trisubstituted aryl guanidines.
引用
收藏
页码：6124 / 6127
页数：4
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