One-Pot Copper-Catalyzed Three-Component Synthesis of Quinoxalines by Condensation and C-N Bond Formation

被引：13
|
作者：
Yuan, Hua [1 ,2 ]
Li, Kangning [1 ,2 ]
Chen, Yongxin [1 ,2 ]
Wang, Yu [1 ,2 ]
Cui, Jiaojiao [1 ,2 ]
Chen, Baohua [1 ,2 ]
机构：
[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China
[2] Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China
来源：
SYNLETT | 2013年 / 24卷 / 17期
基金：
中国国家自然科学基金;
关键词：
quinoxalines; arylacetaldehydes; sodium azide; three-component reaction; O-PHENYLENEDIAMINES; MOLECULAR-IODINE; DERIVATIVES; INHIBITORS; WATER;
D O I：
10.1055/s-0033-1339797
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel way of synthesizing quinoxalines has been developed that involves condensation and C-N bond formation in a copper-catalyzed, one-pot, three-component reaction. The reaction was optimized when 2-iodoanilines (1.0 equiv), arylacetaldehydes (2.0 equiv), sodium azide (1.2 equiv), CuI (10mol%), DMEDA (10mol%), and K2CO3 (1.0 equiv) were reacted in DMSO at 80 degrees C for 20hours. This approach was used to directly synthesize a variety of quinoxalines in moderate to good yields.
引用
收藏
页码：2315 / 2319
页数：5
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