Stem cells and neuropoiesis in the adult human brain

被引:71
|
作者
Steindler, DA
Pincus, DW
机构
[1] Univ Florida, Coll Med, Program Stem Cell Biol, McKnight Brain Inst,Dept Neurosci, Gainesville, FL 32610 USA
[2] Univ Florida, Coll Med, Program Stem Cell Biol, McKnight Brain Inst,Dept Neurosurg, Gainesville, FL 32610 USA
[3] Univ Florida, Coll Med, Program Stem Cell Biol, Shands Canc Ctr, Gainesville, FL 32610 USA
来源
LANCET | 2002年 / 359卷 / 9311期
关键词
D O I
10.1016/S0140-6736(02)08096-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Stem cells in adult tissues have attracted a great deal of interest. These cells are self-renewing and can give rise to diverse progeny. An extraordinary finding was the presence of stem cells in the mature human brain. This tissue was previously believed incapable of generating new neurons, but neuropoiesis Is now an established phenomenon in the adult brains of mammals, including human beings. This persistent neurogenesis has potential therapeutic applications for various neurological disorders as a source for tissue engraftment and as self-repair by a person's own indigenous population of pluripotent cells or biogenic by-products of their proliferation and differentiation.
引用
收藏
页码:1047 / 1054
页数:8
相关论文
共 50 条
  • [31] Stem cells and functional neurogenesis in the adult brain
    Cassidy, RM
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2002, 10 : 60 - 60
  • [32] Stem cells of the adult mammalian brain and their niche
    Basak, O.
    Taylor, V.
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2009, 66 (06) : 1057 - 1072
  • [33] Endogenous neural stem cells in the adult brain
    Jin, Kunlin
    Galvan, Veronica
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2007, 2 (03) : 236 - 242
  • [34] Adult Stem Cells in the Human Testis
    Goossens, Ellen
    Tournaye, Herman
    SEMINARS IN REPRODUCTIVE MEDICINE, 2013, 31 (01) : 39 - 48
  • [35] Adult human olfactory stem cells
    Roisen, FJ
    Klueber, KM
    Lu, CL
    Hatcher, LM
    Dozier, A
    Shields, CB
    Maguire, S
    BRAIN RESEARCH, 2001, 890 (01) : 11 - 22
  • [36] Sources for adult human stem cells
    Lewis, R
    SCIENTIST, 2003, 17 (12): : 21 - 21
  • [37] Calcium Channels in Adult Brain Neural Stem Cells and in Glioblastoma Stem Cells
    Coronas, Valerie
    Terrie, Elodie
    Deliot, Nadine
    Arnault, Patricia
    Constantin, Bruno
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2020, 14
  • [38] Transcriptional Profiling of Adult Neural Stem-Like Cells from the Human Brain
    Sandberg, Cecilie Jonsgar
    Vik-Mo, Einar O.
    Behnan, Jinan
    Helseth, Eirik
    Langmoen, Iver A.
    PLOS ONE, 2014, 9 (12):
  • [39] Activation of endogenous neural stem cells in the adult human brain following subarachnoid hemorrhage
    Sgubin, D.
    Aztiria, E.
    Perin, A.
    Longatti, P.
    Leanza, G.
    JOURNAL OF NEUROSCIENCE RESEARCH, 2007, 85 (08) : 1647 - 1655
  • [40] Genetically perpetuated human neural stem cells engraft and differentiate into the adult mammalian brain
    Rubio, FJ
    Bueno, C
    Villa, A
    Navarro, B
    Martínez-Serrano, A
    MOLECULAR AND CELLULAR NEUROSCIENCE, 2000, 16 (01) : 1 - 13