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Stem cells and neuropoiesis in the adult human brain
被引:71
|作者:
Steindler, DA
Pincus, DW
机构:
[1] Univ Florida, Coll Med, Program Stem Cell Biol, McKnight Brain Inst,Dept Neurosci, Gainesville, FL 32610 USA
[2] Univ Florida, Coll Med, Program Stem Cell Biol, McKnight Brain Inst,Dept Neurosurg, Gainesville, FL 32610 USA
[3] Univ Florida, Coll Med, Program Stem Cell Biol, Shands Canc Ctr, Gainesville, FL 32610 USA
来源:
关键词:
D O I:
10.1016/S0140-6736(02)08096-0
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Stem cells in adult tissues have attracted a great deal of interest. These cells are self-renewing and can give rise to diverse progeny. An extraordinary finding was the presence of stem cells in the mature human brain. This tissue was previously believed incapable of generating new neurons, but neuropoiesis Is now an established phenomenon in the adult brains of mammals, including human beings. This persistent neurogenesis has potential therapeutic applications for various neurological disorders as a source for tissue engraftment and as self-repair by a person's own indigenous population of pluripotent cells or biogenic by-products of their proliferation and differentiation.
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页码:1047 / 1054
页数:8
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