Stem cells and neuropoiesis in the adult human brain

被引:71
|
作者
Steindler, DA
Pincus, DW
机构
[1] Univ Florida, Coll Med, Program Stem Cell Biol, McKnight Brain Inst,Dept Neurosci, Gainesville, FL 32610 USA
[2] Univ Florida, Coll Med, Program Stem Cell Biol, McKnight Brain Inst,Dept Neurosurg, Gainesville, FL 32610 USA
[3] Univ Florida, Coll Med, Program Stem Cell Biol, Shands Canc Ctr, Gainesville, FL 32610 USA
来源
LANCET | 2002年 / 359卷 / 9311期
关键词
D O I
10.1016/S0140-6736(02)08096-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Stem cells in adult tissues have attracted a great deal of interest. These cells are self-renewing and can give rise to diverse progeny. An extraordinary finding was the presence of stem cells in the mature human brain. This tissue was previously believed incapable of generating new neurons, but neuropoiesis Is now an established phenomenon in the adult brains of mammals, including human beings. This persistent neurogenesis has potential therapeutic applications for various neurological disorders as a source for tissue engraftment and as self-repair by a person's own indigenous population of pluripotent cells or biogenic by-products of their proliferation and differentiation.
引用
收藏
页码:1047 / 1054
页数:8
相关论文
共 50 条
  • [1] Stem cells in the adult human brain
    Ahmed, Aminul I.
    Zaben, Malik
    Gray, William P.
    BRITISH JOURNAL OF NEUROSURGERY, 2011, 25 (01) : 28 - 37
  • [2] Phenotypic and functional characterization of adult brain neuropoiesis
    Scheffler, B
    Walton, NM
    Lin, DD
    Goetz, AK
    Enikolopov, G
    Roper, SN
    Steindler, DA
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (26) : 9353 - 9358
  • [3] Neural stem cells in the adult human brain
    Johansson, CB
    Svensson, M
    Wallstedt, L
    Janson, AM
    Frisén, J
    EXPERIMENTAL CELL RESEARCH, 1999, 253 (02) : 733 - 736
  • [4] Transplantation of stem cells from the adult human brain to the adult rat brain
    Olstorn, Havard
    Moe, Morten C.
    Roste, Geir K.
    Bueters, Tjerk
    Langmoen, Iver A.
    NEUROSURGERY, 2007, 60 (06) : 1089 - 1098
  • [5] Biology and therapy of adult human brain stem cells
    Zhu, Jianhong
    Shen, Yiwen
    Chen, Luping
    Zhang, Helen L.
    CELL RESEARCH, 2008, 18 (Suppl 1) : S113 - S113
  • [6] Biology and therapy of adult human brain stem cells
    Jianhong Zhu
    Yiwen Shen
    Luping Chen
    Helen L Zhang
    Cell Research, 2008, 18 : S113 - S113
  • [7] Transplantation of stem cells from the adult human brain to the adult rat brain - Comments
    Federici, Thais
    Boulis, Nicholas M.
    Liu, Charles Y.
    Pilitsis, Julie G.
    Bakay, Roy A. E.
    NEUROSURGERY, 2007, 60 (06) : 1098 - 1099
  • [8] Transplantation of Stem/Progenitor Cells of Human Brain into Adult Rat Brain
    M. A. Aleksandrova
    A. V. Revishchin
    R. A. Poltavtseva
    L. V. Cherkasova
    V. N. Kleshchinov
    L. I. Korochkin
    G. T. Sukhikh
    Russian Journal of Developmental Biology, 2003, 34 (3) : 131 - 136
  • [9] Correlates between hematopoiesis and neuropoiesis: Neural stem cells
    Quesenberry, PJ
    Hulspas, R
    Joly, M
    Benoit, B
    Engstrom, C
    Rielly, J
    Savarese, T
    Pang, L
    Recht, L
    Ross, A
    Stein, G
    Stewart, M
    JOURNAL OF NEUROTRAUMA, 1999, 16 (08) : 661 - 666
  • [10] CD133 stem cells in adult human brain
    H. T. Hassan
    X. Zhai
    J. A. Goodacre
    Journal of Neuro-Oncology, 2008, 89 : 247 - 248