Mechanism of anticancer activity of buforin IIb, a histone H2A-derived peptide

被引：146
|
作者：
Lee, Hyun Soo [2 ]
Park, Chan Bae [2 ]
Kim, Jung Min [2 ]
Jang, Su A. [2 ]
Park, In Yup [2 ]
Kim, Mi Sun [3 ]
Cho, Ju Hyun [1 ]
Kim, Sun Chang [2 ]
机构：
[1] Gyeongsang Natl Univ, Life Sci Res Inst, Dept Biol, Jinju 660701, South Korea
[2] Korea Adv Inst Sci & Technol, Dept Biol Sci, Taejon 305701, South Korea
[3] Korea Atom Energy Res Inst, Biomass Team, Taejon 305343, South Korea
来源：
CANCER LETTERS | 2008年 / 271卷 / 01期
关键词：
Anticancer peptide; Buforin IIb; Ganglioside; Histone H2A;
D O I：
10.1016/j.canlet.2008.05.041
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Buforin IIb is a novel cell-penetrating anticancer peptide derived from histone H2A. Here we analyzed the anticancer activity and cancer cell-killing mechanism of buforin IIb. Buforin IIb displayed selective cytotoxicity against 62 cancer cell lines by specifically targeting cancer cells through interaction with cell surface gangliosides. It traversed cancer cell membranes without damaging them and accumulated primarily in the nuclei. Once inside the cells, buforin IIb induced mitochondria-dependent apoptosis. In vivo analysis revealed that buforin IIb displayed significant tumor suppression activity in mice with tumor xenograft. Overall, these results suggest that buforin IIb constitutes a novel therapeutic agent for the treatment of cancers. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：47 / 55
页数：9
相关论文
共 50 条
  • [21] Anticancer activity of peptide W-0803 derived from Anoplophoa glabripennis
    Yeom, Jae Ho
    Lee, Jin-Woo
    Hong, Seung Myun
    Lee, Deok Jae
    Park, Dong Choon
    Chung, Namhyun
    APPLIED BIOLOGICAL CHEMISTRY, 2024, 67 (01)
  • [22] Anticancer activity of Pseudomonas aeruginosa derived peptide with iRGD in colon cancer therapy
    Yaghoubi, Atieh
    Movaqar, Aref
    Asgharzadeh, Fereshteh
    Derakhshan, Mohammad
    Ghazvini, Kiarash
    Hasanian, Seyed Mahdi
    Avan, Amir
    Mostafapour, Asma
    Khazaei, Majid
    Soleimanpour, Saman
    IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES, 2023, 26 (07) : 768 - 776
  • [23] Anticancer activity of tuftsin-derived T peptide in postoperative residual tumors
    An, Yinghong
    Li, Linna
    Yang, Dexuan
    Jia, Na
    Xu, Chengwang
    Wang, Qiong
    Wang, Shanshan
    Yuan, Shoujun
    ANTI-CANCER DRUGS, 2014, 25 (08) : 857 - 867
  • [24] Anticancer activity of a synthetic peptide derived from harmoniasin, an antibacterial peptide from the ladybug Harmonia axyridis
    Kim, In-Woo
    Lee, Joon Ha
    Kwon, Young-Nam
    Yun, Eun-Young
    Nam, Sung-Hee
    Ahn, Mi-Young
    Kang, Dong-Chul
    Hwang, Hae Sam
    INTERNATIONAL JOURNAL OF ONCOLOGY, 2013, 43 (02) : 622 - 628
  • [25] Mechanism study on a new antimicrobial peptide Sphistin derived from the N-terminus of crab histone H2A identified in haemolymphs of Scylla paramamosain
    Chen, Bei
    Fan, Dan-Qing
    Zhu, Ke-Xin
    Shan, Zhong-Guo
    Chen, Fang-Yi
    Hou, Lin
    Cai, Ling
    Wang, Ke-Jian
    FISH & SHELLFISH IMMUNOLOGY, 2015, 47 (02) : 833 - 846
  • [26] Depsipeptide (FK228) as a novel histone deacetylase inhibitor: Mechanism of action and anticancer activity
    Lech-Maranda, Ewa
    Robak, Ewa
    Korycka, Anna
    Robak, Tadeusz
    MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2007, 7 (10) : 1062 - 1069
  • [27] Development of a scintillation proximity assay for histone deacetylase using a biotinylated peptide derived from histone-H4
    Nare, B
    Allocco, JJ
    Kuningas, R
    Galuska, S
    Myers, RW
    Bednarek, MA
    Schmatz, DM
    ANALYTICAL BIOCHEMISTRY, 1999, 267 (02) : 390 - 396
  • [28] BR2, a Buforin Derived Cancer Specific Cell Penetrating Peptide for Targeted Delivering of Toxic Agents: a Review Article
    Fatemeh Sadeghi
    Marziyeh Kajbaf
    Fatemeh Shafiee
    International Journal of Peptide Research and Therapeutics, 28
  • [29] Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin
    Arias, Mauricio
    Haney, Evan F.
    Hilchie, Ashley L.
    Corcoran, Jennifer A.
    Hyndman, M. Eric
    Hancock, Robert E. W.
    Vogel, Hans J.
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2020, 1862 (08):
  • [30] Preliminary study on a potential antibacterial peptide derived from histone H2A in hemocytes of scallop Chlamys farreri
    Li, Chenghua
    Song, Linsheng
    Zhao, Jianmin
    Zhu, Ling
    Zou, Huibin
    Zhang, Huan
    Wang, Hao
    Cai, Zhonghua
    FISH & SHELLFISH IMMUNOLOGY, 2007, 22 (06) : 663 - 672
12345