A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma

被引：58

作者：

Gaugler, B

Brouwenstijn, N

Vantomme, V

Szikora, JP

VanderSpek, CW

Patard, JJ

Boon, T

Schrier, P

VandenEynde, BJ

机构：

[1] LUDWIG INST CANC RES,BRUSSELS BRANCH,B-1200 BRUSSELS,BELGIUM

[2] UNIV CATHOLIQUE LOUVAIN,CELLULAR GENET UNIT,B-1200 BRUSSELS,BELGIUM

[3] ACAD HOSP LEIDEN,DEPT CLIN ONCOL,NL-2300 RC LEIDEN,NETHERLANDS

来源：

IMMUNOGENETICS | 1996年 / 44卷 / 05期

关键词：

TUMOR-INFILTRATING LYMPHOCYTES; HUMAN-MELANOMA; HLA-A2; MELANOMAS; CELL CARCINOMA; IDENTIFICATION; INTERLEUKIN-2; EXPRESSION; CANCER; CODES; AMPLIFICATION;

D O I：

10.1007/s002510050133

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Previous reports have described antigens that are recognized on human melanoma cells by autologous cytolytic T lymphocytes (CTL). The genes coding for a number of these antigens have been identified. Here we report the cloning of a gene that codes for an antigen recognized by autologous CTL on a human renal carcinoma cell line. This antigen is presented by HLA-B7 and is encoded by a new gene that we have named RAGE1. No expression of RAGE1 was found in normal tissues other than retina. RAGE1 expression was found in only one of 57 renal cell carcinoma samples, and also in some sarcomas, infiltrating bladder carcinomas, and melanomas. This represents the first identification of an antigen recognized by autologous CTL on a renal tumor.

引用

页码：323 / 330

页数：8

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