Peritoneal Sarcomatosis in Pediatric Malignancies

被引：20

作者：

Huh, Winston W. ^{[1
]}

Fitzgerald, Nancy E. ^{[2
]}

Mahajan, Anita ^{[3
]}

Hayes-Jordan, Andrea ^{[4
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Childrens Canc Hosp, Div Pediat, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Diagnost Radiol, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Surg, Houston, TX 77030 USA

来源：

PEDIATRIC BLOOD & CANCER | 2013年 / 60卷 / 01期

关键词：

childhood cancer; intraperitoneal; pediatric; sarcoma; sarcomatosis; PERIOPERATIVE INTRAPERITONEAL CHEMOTHERAPY; ROUND-CELL TUMOR; GASTROINTESTINAL STROMAL TUMORS; POSITRON-EMISSION-TOMOGRAPHY; HEPATOCYTE GROWTH-FACTOR; SOFT-TISSUE SARCOMA; CYTOREDUCTIVE SURGERY; PHOTODYNAMIC THERAPY; MORTALITY ASSESSMENT; COLORECTAL-CANCER;

D O I：

10.1002/pbc.24293

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Peritoneal sarcomatosis (PSC) is defined as peritoneal involvement of multiple sarcomatous tumors. Desmoplastic small round cell tumors (DSRCT) and rhabdomyosarcomas are the most common pediatric PSC cases. PSC has been treated with chemotherapy and mainly palliative surgery, but long-term outcome has been poor. New imaging technologies have improved the evaluation of disease extent and patterns of peritoneal dissemination, and cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is being evaluated as a treatment option to prolong remission in pediatric patients. We will review the clinical characteristics, potential biologic mechanisms, radiographic characteristics, and potential therapies for pediatric PSC patients. Pediatr Blood Cancer 2013; 60: 12-17. (C) 2012 Wiley Periodicals, Inc.

引用

页码：12 / 17

页数：6

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