Obesity and Type 2 Diabetes are Associated with an Increased Risk of Developing Cancer and a Worse Prognosis; Epidemiological and Mechanistic Evidence

被引：100
|
作者：
LeRoith, D.
Novosyadlyy, R.
Gallagher, E. J.
Lann, D.
Vijayakumar, A.
Yakar, S.
机构：
[1] Division of Endocrinology and Diabetes, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029-6574, One Gustave L. Levy Place
来源：
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 2008年 / 116卷
关键词：
diabetes; obesity; cancer; epidemiology;
D O I：
10.1055/s-2008-1081488
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Both obesity and Type 2 diabetes are independently associated with an increased risk of developing cancer and an increased mortality. The etiology is yet to be determined but insulin resistance and hyperinsulinemia maybe important factors. Hyperglycemia, hyperlipidemia and inflammatory cytokines in addition to the insulin-like growth factors are also possible factors involved in the process.
引用
收藏
页码：S4 / S6
页数：3
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