Polysialic Acid as a Novel Regulator of AAV Tropism in the Developing Brain

被引：0
|
作者：
Murlidharan, Giridhar [1 ,2 ]
Asokan, Aravind [1 ,2 ]
机构：
[1] Univ N Carolina, Dept Genet, Chapel Hill, NC USA
[2] Univ N Carolina, Gene Therapy Ctr, Chapel Hill, NC USA
来源：
MOLECULAR THERAPY | 2015年 / 23卷
关键词：
D O I：
10.1016/S1525-0016(16)33874-6
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
265
引用
收藏
页码：S106 / S106
页数：1
相关论文
共 50 条
  • [41] POLYSIALIC ACID UNITS ARE SPATIALLY AND TEMPORALLY EXPRESSED IN DEVELOPING POSTNATAL RAT-KIDNEY
    ROTH, J
    TAATJES, DJ
    BITTERSUERMANN, D
    FINNE, J
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (07) : 1969 - 1973
  • [42] Analysis of Gene Expression, Tissue Tropism, and Safety of Novel AAV Variants in Mice Following Intravenous Administration
    Neal, Tawny
    Tobia, Steven
    Bauer, Alex
    Ni, Ming
    Gasmi, Mehdi
    Keravala, Annahita
    MOLECULAR THERAPY, 2017, 25 (05) : 52 - 52
  • [43] Discovery of Novel AAV Capsids with Enhanced Skeletal Muscle Tropism Following Directed Evolution in Cynomolgus Macaque
    Jin, Quan
    Hung, Ka Ying Sharon
    Kashyap, Samneet
    Rouse, Emily
    Kelemen, Margaret
    Xiang, Lucia
    Utturkar, Aditya
    Chittoda, Misha
    Sampath, Harini
    Bourque, Shawn
    Desmarais, Samantha
    Deng, Shuyun
    Chen, Wei Tong
    Gianni, Davide
    Suh, Junghae
    Yuan, Yuan
    MOLECULAR THERAPY, 2023, 31 (04) : 556 - 556
  • [44] Brain development needs sugar: the role of polysialic acid in controlling NCAM functions
    Muehlenhoff, Martina
    Oltmann-Norden, Imke
    Weinhold, Birgit
    Hildebrandt, Herbert
    Gerardy-Schahn, Rita
    BIOLOGICAL CHEMISTRY, 2009, 390 (07) : 567 - 574
  • [45] Intravenous delivery of a novel AAV capsid with improved PNS tropism reduces underlying Pompe disease pathology
    Kevany, Brian
    Padegimas, Linas
    Miller, Timothy
    MOLECULAR GENETICS AND METABOLISM, 2020, 129 (02) : S87 - S87
  • [46] Identification of Novel AAV Capsid Variants with Enhanced Tropism for the Canine Outer Retina Following Intravitreal Delivery
    Byrne, Leah C.
    Visel, Meike
    Dufour, Valerie
    Marinho, Felipe Pompeo
    Aguirre, Gustavo D.
    Beltran, William A.
    Flannery, John G.
    Schaffer, David V.
    MOLECULAR THERAPY, 2016, 24 : S244 - S245
  • [47] An in vivo brain–bacteria interface: the developing brain as a key regulator of innate immunity
    Celia Herrera-Rincon
    Jean-Francois Paré
    Christopher J. Martyniuk
    Sophia K. Jannetty
    Christina Harrison
    Alina Fischer
    Alexandre Dinis
    Vishal Keshari
    Richard Novak
    Michael Levin
    npj Regenerative Medicine, 5
  • [48] Novel caprine adeno-associated virus (AAV) capsid (AAV-Go.1) is closely related to the primate AAV-5 and has unique tropism and neutralization properties
    Arbetman, AE
    Lochrie, M
    Zhou, SZ
    Wellman, J
    Scallan, C
    Doroudchi, MM
    Randlev, B
    Patarroyo-White, S
    Liu, TY
    Smith, P
    Lehmkuhl, H
    Hobbs, LA
    Pierce, GF
    Colosi, P
    JOURNAL OF VIROLOGY, 2005, 79 (24) : 15238 - 15245
  • [49] AAV-S: A Novel AAV Vector Selected in Brain Transduces the Cochlea with High Efficiency
    Hanlon, Killian S.
    Ivanchenko, Maryna V.
    Peters, Cole W. D.
    Li, Yaqiao
    Tamvakologos, Panos I.
    Corey, David P.
    Maguire, Casey A.
    MOLECULAR THERAPY, 2020, 28 (04) : 76 - 77
  • [50] Unique Glycan Signatures Regulate Adeno-Associated Virus Tropism in the Developing Brain
    Murlidharan, Giridhar
    Corriher, Travis
    Ghashghaei, H. Troy
    Asokan, Aravind
    JOURNAL OF VIROLOGY, 2015, 89 (07) : 3976 - 3987
12345