Expansion of hematopoietic stem/progenitor cells

被引：23
|
作者：
Hai-Jiang, Wu [1 ]
Xin-Na, Deng [2 ]
Hui-Jun, Duan [1 ]
机构：
[1] Hebei Med Univ, Dept Pathol, Shijiazhuang, Peoples R China
[2] Hebei Med Univ, Dept Oncol, Affiliated Hosp 4, Shijiazhuang, Peoples R China
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 2008年 / 83卷 / 12期
关键词：
D O I：
10.1002/ajh.21262
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hematopoietic stem/progenitor cells (HSPCs) transplantation is hampered by the low number of stem cells per sample. To tackle this obstacle, several protocols for expansion of HSPCs in vitro are currently in development, such as the use of cytokine cocktails, coculture with mesenchymal stem cells as feeder cells, and cell culture in bioreactors. With the progress in the understanding of the molecular and cellular mechanisms regulating HSPCs maintenance and expansion, more recent approaches have involved transcription regulation, cell cycle regulation, telomerase regulation, and chromatin-modifying agents. The potential clinical application and safety issues relevant to the expanded HSPCs are also discussed in this review. Am. J. Hematol. 83:922-926, 2008. (c) 2008 Wiley-Liss, Inc.
引用
收藏
页码：922 / 926
页数：5
相关论文
共 50 条
  • [41] Stroma-conditioned media improve expansion of human primitive hematopoietic stem cells and progenitor cells
    DA Breems
    EAW Blokland
    RE Ploemacher
    Leukemia, 1997, 11 : 142 - 150
  • [42] Stroma-conditioned media improve expansion of human primitive hematopoietic stem cells and progenitor cells
    Breems, DA
    Blokland, EAW
    Ploemacher, RE
    LEUKEMIA, 1997, 11 (01) : 142 - 150
  • [43] Synergistic Integration of Mesenchymal Stem Cells and Hydrostatic Pressure in the Expansion and Maintenance of Human Hematopoietic/Progenitor Cells
    Kang, Yun Gyeong
    Jeong, Jee-Yeong
    Lee, Tae-Hee
    Lee, Ho Sup
    Shin, Jung-Woog
    STEM CELLS INTERNATIONAL, 2018, 2018
  • [44] STEMPRO™ HSC EXPANSION MEDIUM ( PROTOTYPE) SUPPORTS SUPERIOR EXPANSION OF HUMAN HEMATOPOIETIC STEM-PROGENITOR CELLS
    Sei, J.
    Moses, B.
    Becker, A. Harris
    Kim, M.
    Kaur, N.
    Vemuri, M.
    Civin, C.
    CYTOTHERAPY, 2019, 21 (05) : S64 - S65
  • [45] Expansion and tagging of hematopoietic stem cells
    Botezatu, Lacramioara
    May, Tobias
    Riemer, Pamela
    Hauser, Hansjoerg
    Wirth, Dagmar
    HUMAN GENE THERAPY, 2009, 20 (11) : 1461 - 1462
  • [46] In vitro expansion of hematopoietic stem cells
    Ogawa, M
    Yonemura, Y
    Ku, H
    STEM CELLS, 1997, 15 : 7 - 11
  • [47] Ex vivo expansion of hematopoietic progenitor cells and mature cells
    McNiece, I
    Briddell, R
    EXPERIMENTAL HEMATOLOGY, 2001, 29 (01) : 3 - 11
  • [48] Differentiation of Hematopoietic Stem/Progenitor Cells From Embryonic Stem Cells
    Chao, Yang
    Xi, Jia-Fei
    Wen, Yue
    Pei, Xue-Tao
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2009, 36 (07) : 797 - 802
  • [49] Hematopoietic stem and progenitor cells in adhesive microcavities
    Kurth, Ina
    Franke, Katja
    Pompe, Tilo
    Bornhaeuser, Martin
    Werner, Carsten
    INTEGRATIVE BIOLOGY, 2009, 1 (5-6) : 427 - 434
  • [50] Lineage development of hematopoietic stem and progenitor cells
    Giebel, Bernd
    Punzel, Michael
    BIOLOGICAL CHEMISTRY, 2008, 389 (07) : 813 - 824
12345