Distinguishing Truncated and Normal MUC1 Glycoform Targeting from Tn-MUC1-Specific CAR T Cells: Specificity Is the Key to Safety

被引:20
|
作者
Posey, Avery D., Jr. [1 ,2 ]
Clausen, Henrik [3 ,4 ]
June, Carl H. [1 ,2 ]
机构
[1] Univ Penn, Ctr Cellular Immunotherapies, Philadelphia, PA 19104 USA
[2] Univ Penn, Parker Inst Canc Immunotherapy, Philadelphia, PA 19104 USA
[3] Univ Copenhagen, Fac Hlth Sci, Copenhagen Ctr Glyc, Dept Cellular & Mol Med, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark
[4] Univ Copenhagen, Fac Hlth Sci, Copenhagen Ctr Glyc, Dept Odontol, Blegdamsvej 3, DK-2200 Copenhagen N, Denmark
关键词
CHIMERIC ANTIGEN RECEPTOR; PROTEIN;
D O I
10.1016/j.immuni.2016.10.015
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:947 / 948
页数:2
相关论文
共 50 条
  • [21] CAR T That Targets MUC1 Transmembrane Cleavage Product Has Increased Persistence and Kills Low Antigen Cells
    Bamdad, Cynthia
    Smagghe, Benoit J.
    Stewart, Andrew K.
    Carter, Mark G.
    Page, Danica M.
    Yi, Kevin K.
    Grant, Trevor J.
    Nash, Jac-Leen S.
    Reale, Laura M.
    Nash, Michael J.
    MOLECULAR THERAPY, 2022, 30 (04) : 578 - 578
  • [22] CAR T Cells Targeting the Tumor MUC1 Glycoprotein Reduce Triple-Negative Breast Cancer Growth (vol 10, 1149, 2019)
    Zhou, Ru
    Yazdanifar, Mahboubeh
    Roy, Lopamudra Das
    Whilding, Lynsey M.
    Gavrill, Artemis
    Maher, John
    Mukherjee, Pinku
    FRONTIERS IN IMMUNOLOGY, 2020, 11
  • [23] Autologous dendritic cells or cells expressing both B7-1 and MUC1 can rescue tumor-specific cytotoxic T lymphocytes from MUC1-mediated apoptotic cell death
    Kontani, K
    Taguchi, O
    Narita, T
    Hiraiwa, N
    Sawai, S
    Hanaoka, J
    Ichinose, M
    Tezuka, N
    Inoue, S
    Fujino, S
    Kannagi, R
    JOURNAL OF LEUKOCYTE BIOLOGY, 2000, 68 (02) : 225 - 232
  • [24] Combined MUC1-specific nanobody-tagged PEG-polyethylenimine polyplex targeting and transcriptional targeting of tBid transgene for directed killing of MUC1 over-expressing tumour cells
    Sadeqzadeh, Elham
    Rahbarizadeh, Fatemeh
    Ahmadvand, Davoud
    Rasaee, Mohammad J.
    Parhamifar, Ladan
    Moghimi, S. Moein
    JOURNAL OF CONTROLLED RELEASE, 2011, 156 (01) : 85 - 91
  • [25] MUC1 in human milk blocks transmission of human immunodeficiency virus from dendritic cells to T cells
    Saeland, Eirikur
    de Jong, Marein A. W. P.
    Nabatov, Alexey A.
    Kalay, Hakan
    Geijtenbeek, Teunis B. H.
    van Kooyk, Yvette
    MOLECULAR IMMUNOLOGY, 2009, 46 (11-12) : 2309 - 2316
  • [26] Phase I first-in-human MUC1*targeted autologous CAR T cells for the treatment of metastatic breast cancers
    Bamdad, Cynthia Carol
    Mortimer, Joanne E.
    Yuan, Yuan
    Specht, Jennifer M.
    Stewart, Andrew K.
    Smagghe, Benoit J.
    Lin, Stephen C.
    Carter, Mark G.
    Synold, Tim W.
    Fleming, Mark D.
    Hamilton, Stanley R.
    Parekh, Vishwas
    Walkley, Danica M.
    Liu-Michael, Qing
    Yi, Kevin R.
    Nash, Jac-Leen S.
    Nash, Michael J.
    Forman, Stephen J.
    CANCER RESEARCH, 2024, 84 (07)
  • [27] Tumor rejection and long term protection in MUC1 transgenic mice is mediated by MUC1-specific, IFN-gamma producing CD8+T cells, in the absence of CD4+T cells
    Soares, MM
    Finn, OJ
    FASEB JOURNAL, 2001, 15 (04): : A656 - A656
  • [28] Enrichment of functional CD8 memory T cells specific for MUC1 in bone marrow of patients with multiple myeloma
    Choi, C
    Witzens, M
    Bucur, M
    Feuerer, M
    Sommerfeldt, N
    Trojan, A
    Ho, A
    Schirrmacher, V
    Goldschmidt, H
    Beckhove, P
    BLOOD, 2005, 105 (05) : 2132 - 2134
  • [29] Enrichment of functional CD8 memory T cells specific for MUC1 in Bone Marrow of Multiple Myeloma Patients
    M Witzens
    C Choi
    M Bucur
    M Feuerer
    N Sommerfeldt
    A Trojan
    A Ho
    V Schirrmacher
    H Goldschmidt
    P Beckhove
    Cancer Cell International, 4 (Suppl 1)
  • [30] Modulation of MUC1 mucin as an escape mechanism of breast cancer cells from autologous cytotoxic T-lymphocytes
    K Kontani
    O Taguchi
    T Narita
    M Izawa
    N Hiraiwa
    K Zenita
    T Takeuchi
    H Murai
    S Miura
    R Kannagi
    British Journal of Cancer, 2001, 84 : 1258 - 1264