T-box;
Tbx4;
Tbx5;
zebrafish;
gene expression;
embryogenesis;
fin bud;
D O I:
10.1016/S0925-4773(99)00126-4
中图分类号:
Q [生物科学];
学科分类号:
07 ;
0710 ;
09 ;
摘要:
In here we report the identification of two new members of the T-box gene family, Zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
机构:
Univ Chicago, Comm Dev Regenerat & Stem Cell Biol, Chicago, IL 60637 USAUniv Chicago, Comm Dev Regenerat & Stem Cell Biol, Chicago, IL 60637 USA
Anderson, Erin A. T. Boyle
Ho, Robert K.
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机构:
Univ Chicago, Dept Organismal Biol & Anat, 1025 E 57Th St, Chicago, IL 60637 USAUniv Chicago, Comm Dev Regenerat & Stem Cell Biol, Chicago, IL 60637 USA
机构:
Northwestern Univ, Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL 60611 USA
Camarata, Troy
Topczewski, Jacek
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机构:
Northwestern Univ, Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL 60611 USA
Topczewski, Jacek
Simon, Hans-Georg
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机构:
Northwestern Univ, Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL 60611 USANorthwestern Univ, Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL 60611 USA