Differential expression of Tbx4 and Tbx5 in Zebrafish fin buds

被引：59
|
作者：
Tamura, K [1 ]
Yonei-Tamura, S [1 ]
Belmonte, KCI [1 ]
机构：
[1] Salk Inst Biol Studies, Salk Inst Biol Studies, La Jolla, CA 92037 USA
来源：
MECHANISMS OF DEVELOPMENT | 1999年 / 87卷 / 1-2期
基金：
美国国家科学基金会; 日本学术振兴会;
关键词：
T-box; Tbx4; Tbx5; zebrafish; gene expression; embryogenesis; fin bud;
D O I：
10.1016/S0925-4773(99)00126-4
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In here we report the identification of two new members of the T-box gene family, Zf-tbx5 and zf-tbx4, from the Zebrafish, Danio rerio. The amino acid sequences within the T-box domain share high homology with the mouse, chick, and newt orthologs. Whole mount in situ hybridization revealed specific expression of these genes in the eye and Fin buds. zf-tbx5 expression is restricted to the pectoral Fin bud, whilst zf-tbx4 transcripts are confined in the pelvic Fin bud. These results reveal the conserved expression pattern of Tbx5 and Tbx4 during appendage development in all animal species studied to date. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：181 / 184
页数：4
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