Efficient α-alkylation and silylation of aromatic O-tert-butyldimethylsilyl ketoximes

被引：5
|
作者：
Ortiz-Marciales, M [1 ]
De Jesús, M [1 ]
Quiñones, L [1 ]
Figueroa, D [1 ]
Montes, YL [1 ]
Burgos, C [1 ]
Moctezuma, B [1 ]
机构：
[1] Univ Puerto Rico, Dept Chem, Humacao Coll, CUH Stn, Humacao, PR 00791 USA
来源：
TETRAHEDRON | 1999年 / 55卷 / 42期
关键词：
alkylation; alkyl halide; benzylation; oxime; silicon and compounds; silicon halides;
D O I：
10.1016/S0040-4020(99)00731-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The a-alkylation and silylation of para substituted acetophenones, 1- and 2-indanone (O-TBS) oximes at various reaction conditions, were studied. Optimum conversions from 82% to 100% were afforded for the alkylation and silylation of these (O-TBS) ketoximes with LDA at -78 degrees C, using electrophiles, such as, methyl iodide, ethylbromide, benzyl bromide and trimethylchlorosilane. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：12275 / 12286
页数：12
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