Cells of origin for cancer: an updated view from prostate cancer

被引：51
|
作者：
Xin, L. [1 ,2 ,3 ]
机构：
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Pathol & Immunol, Houston, TX 77030 USA
[3] Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA
来源：
ONCOGENE | 2013年 / 32卷 / 32期
关键词：
cells of origin; prostate cancer; prostate stem cells; lineage hierarchy; lineage tracing; tumor initiation; UROGENITAL SINUS MESENCHYME; EPITHELIAL STEM-CELLS; MURINE PROSTATE; MAMMARY-GLAND; INTERMEDIATE CELLS; TUMOR INITIATION; MIR-200; FAMILY; BASAL-CELLS; EXPRESSION; DIFFERENTIATION;
D O I：
10.1038/onc.2012.541
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cells of origin for cancer are the cells within tissues that serve as the target for transformation. Understanding the nature of these cells will benefit disease prevention, diagnosis and prognosis. During the past decade, much progress has been made in understanding the cellular origin for prostate cancer. This review aims to summarize the previous findings, describe the most recent results and discuss some controversies and unresolved issues in this field.
引用
收藏
页码：3655 / 3663
页数：9
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