Methylglyoxal comes of AGE

被引：146
|
作者：
Ramasamy, R [1 ]
Yan, SF [1 ]
Schmidt, AM [1 ]
机构：
[1] Columbia Univ, Med Ctr, Dept Surg, New York, NY 10032 USA
来源：
CELL | 2006年 / 124卷 / 02期
关键词：
D O I：
10.1016/j.cell.2006.01.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The posttranslational modification of proteins by methylglyoxal, a highly reactive compound derived from glycolysis, may contribute to aging, diabetes, and other disorders. In this issue of Cell, Brownlee and colleagues (Yao et al., 2006) demonstrate a specific mechanism by which methylglyoxal modifies a transcriptional corepressor to enhance gene expression.
引用
收藏
页码：258 / 260
页数：3
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