A blooming resolvase at chromosomal fragile sites

被引：7
|
作者：
Pellicioli, Achille [1 ]
Muzi-Falconi, Marco [1 ]
机构：
[1] Univ Milan, Dipartimento Biosci, I-20133 Milan, Italy
来源：
NATURE CELL BIOLOGY | 2013年 / 15卷 / 08期
关键词：
REPLICATION STRESS; INSTABILITY; COMMON; STABILITY;
D O I：
10.1038/ncb2812
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Common fragile sites (CFSs) are chromosomal regions that are prone to form breaks or gaps during mitosis, in particular following replication stress. The mechanisms modulating CFS expression and promoting safe chromatid transmission to daughter cells are not clear. Now CFS expression is shown to reflect the activity of the MUS81-EME1 resolvase complex which cooperates with the dissolving action of the BLM helicase to prevent uncontrolled chromosome breakage and to promote genome integrity.
引用
收藏
页码：883 / 885
页数：3
相关论文
共 50 条
  • [31] THE CIS-CONFIGURATION EFFECTS OF RARE CHROMOSOMAL FRAGILE SITES
    COTE, GB
    [J]. CLINICAL GENETICS, 1990, 37 (06) : 470 - 472
  • [32] CHROMOSOMAL FRAGILE SITES IN PATIENTS WITH BIPOLAR AFFECTIVE-DISORDER
    KAPALANGA, J
    ZHANG, H
    WANG, M
    WALDRON, J
    LAWSON, S
    ABRAHAM, G
    OWEN, J
    BENDENA, W
    WHITE, BN
    HOLDEN, JJA
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 1995, 57 (04) : 659 - 659
  • [33] DNA Secondary Structure at Chromosomal Fragile Sites in Human Disease
    Thys, Ryan G.
    Lehman, Christine E.
    Pierce, Levi C. T.
    Wang, Yuh-Hwa
    [J]. CURRENT GENOMICS, 2015, 16 (01) : 60 - 70
  • [34] PROTEASE INHIBITOR (PI) PHENOTYPE OF INDIVIDUALS WITH CHROMOSOMAL FRAGILE SITES
    MULLEY, JC
    SUTHERLAND, GR
    [J]. ANNALES DE GENETIQUE, 1983, 26 (03): : 143 - 146
  • [35] CHROMOSOMAL FRAGILE SITES IN PATIENTS WITH BENIGN AND MALIGNANT-TUMORS
    MURATA, M
    OTSUKA, M
    TAKAHASHI, E
    HORI, T
    [J]. JAPANESE JOURNAL OF HUMAN GENETICS, 1988, 33 (02): : 223 - 223
  • [36] CHROMOSOMAL FRAGILE SITES AND CANCER-SPECIFIC BREAKPOINTS - A MODERATING VIEWPOINT
    LEBEAU, MM
    [J]. CANCER GENETICS AND CYTOGENETICS, 1988, 31 (01) : 55 - 61
  • [37] Common fragile sites associated with the breakpoints of chromosomal aberrations in hematologic neoplasms
    Gümüs, G
    Sunguroglu, A
    Tükün, A
    Sayin, DB
    Bökesoy, I
    [J]. CANCER GENETICS AND CYTOGENETICS, 2002, 133 (02) : 168 - 171
  • [38] COMMON FRAGILE SITES - THEIR PREVALENCE IN SUBJECTS WITH CONSTITUTIONAL AND ACQUIRED CHROMOSOMAL INSTABILITY
    TEDESCHI, B
    PORFIRIO, B
    VERNOLE, P
    CAPOROSSI, D
    DALLAPICCOLA, B
    NICOLETTI, B
    [J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1987, 27 (02): : 471 - 482
  • [39] ANALYSIS ON THE EXPRESSION OF CHROMOSOMAL FRAGILE SITES BY SOMATIC-CELL HYBRIDIZATION
    HORI, T
    TAKAHASHI, E
    MURATA, M
    AYUSAWA, D
    SENO, T
    [J]. JAPANESE JOURNAL OF GENETICS, 1986, 61 (06): : 581 - 581
  • [40] CHROMOSOMAL FRAGILE SITES - MOLECULAR TEST OF THE DELAYED-REPLICATION MODEL
    LAIRD, CD
    HANSEN, RS
    CANFIELD, TK
    LAMB, MM
    GARTLER, SM
    [J]. COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1993, 58 : 633 - 635
12345