Microscopic analysis of opacification in Ioflex® hydrophilic acrylic intraocular lenses

Five cases of intraocular lens (IOL) opacification in patients implanted with the Mediphacos Ioflex (R) IOL are described. Clinical data in each case was obtained from the patient's medical record. The five explanted IOLs underwent gross and light microscopic analysis. Selected lenses were processed for further evaluation and multiple sagittal cuts were stained with the alizarin red and von Kossa methods. Light microscope analysis confirmed the presence of deposits on and within the lens, which stained positive for calcium. The reason why calcification has occurred in these cases remains unclear, but surgeons should be aware of this potential late postoperative complication.