Mechanisms involved in α6β1-integrin-mediated Ca2+ signalling

被引：24
|
作者：
Schöttelndreier, H
Potter, BVL
Mayr, GW
Guse, AH
机构：
[1] Univ Hamburg, Hosp Eppendorf, Div Cellular Signal Transduct, Inst Med Biochem & Mol Biol, D-20246 Hamburg, Germany
[2] Univ Bath, Dept Pharm & Pharmacol, Wolfson Lab Med Chem, Bath BA2 7AY, Avon, England
来源：
CELLULAR SIGNALLING | 2001年 / 13卷 / 12期
基金：
英国惠康基金;
关键词：
integrin; extracellular matrix; Ca2+ signalling; inositol 1,4,5-trisphosphate; cyclic ADP-ribose; capacitative Ca2+ entry; SKF; 96365;
D O I：
10.1016/S0898-6568(01)00225-X
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Contact of Jurkat T-lymphocytes with the extracellular matrix (ECM) protein laminin resulted in long-lasting alpha6 beta1-integrin-mediated Ca2+ signalling. Both Ca2+ release from thapsigargin-sensitive Ca2+ stores and capacitative Ca2+ entry via Ca2+ channels sensitive to SKF 96365 constitute important parts of this process. Inhibition of alpha6 beta1-integrin-mediated Ca2+ signalling by (1) the src kinase inhibitor PP2, (2) the PLC inhibitor U73122, and (3) the cyclic adenosine diphosphoribose (cADPR) antagonist 7-deaza-8-Br-cADPR indicate the involvement of src tyrosine kinases and the Ca2+-releasing second messengers D-myo-inositol 1.4,5-trisphosphate (InSP3) and cADPR. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：895 / 899
页数：5
相关论文
共 50 条
  • [31] Krit1 modulates β1-integrin-mediated endothelial cell proliferation -: Comments
    Awad, Issam A.
    Crowley, R. Webster
    Mendel, Ricky
    Dumont, Aaron S.
    NEUROSURGERY, 2008, 63 (03) : 578 - 578
  • [32] The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration
    Zech, Tobias
    Calaminus, Simon D. J.
    Caswell, Patrick
    Spence, Heather J.
    Carnell, Michael
    Insall, Robert H.
    Norman, Jim
    Machesky, Laura M.
    JOURNAL OF CELL SCIENCE, 2011, 124 (22) : 3753 - 3759
  • [33] Autocrine motility factor stimulates β 1-integrin-mediated invasion of hepatoma cells
    Torimura, T
    Ueno, T
    Kim, KC
    Ogata, R
    Harada, M
    Kawaguchi, T
    Sakisaka, S
    Sata, M
    Tanikawa, K
    Watanabe, H
    HEPATOLOGY, 1998, 28 (04) : 513A - 513A
  • [34] β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis
    Hussain, Mohammed Tayab
    Austin-Williams, Shani
    Wright, Thomas Dudley
    Dhawan, Umesh Kumar
    Pinto, Andreia L.
    Cooper, Dianne
    Norling, Lucy V.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (09)
  • [35] Influence of ER leak on resting cytoplasmic Ca2+ and receptor-mediated Ca2+ signalling in human macrophage
    Layhadi, Janice A.
    Fountain, Samuel J.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 487 (03) : 633 - 639
  • [36] Molecular genetics of Ca2+ stores and intracellular Ca2+ signalling
    Sorrentino, V
    Rizzuto, R
    TRENDS IN PHARMACOLOGICAL SCIENCES, 2001, 22 (09) : 459 - 464
  • [37] The regulation of integrin function by Ca2+
    Leitinger, B
    McDowall, A
    Stanley, P
    Hogg, N
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2000, 1498 (2-3): : 91 - 98
  • [38] β2-Integrin-Mediated Adhesion and Intracellular Ca2+ Release in Human Eosinophils
    Jennifer L. Bankers-Fulbright
    Kathleen R. Bartemes
    Gail M. Kephart
    Hirohito Kita
    Scott M. O’Grady
    Journal of Membrane Biology, 2009, 228 : 99 - 109
  • [39] β2-Integrin-Mediated Adhesion and Intracellular Ca2+ Release in Human Eosinophils
    Bankers-Fulbright, Jennifer L.
    Bartemes, Kathleen R.
    Kephart, Gail M.
    Kita, Hirohito
    O'Grady, Scott M.
    JOURNAL OF MEMBRANE BIOLOGY, 2009, 228 (02): : 99 - 109
  • [40] Integrin-mediated intracellular Ca2+ signaling in Jurkat T lymphocytes
    Weismann, M
    Guse, AH
    Sorokin, L
    Broker, B
    Frieser, M
    Hallmann, R
    Mayr, GW
    JOURNAL OF IMMUNOLOGY, 1997, 158 (04): : 1618 - 1627
12345