Generation of Fas-independent CD4+cytotoxic T-cell clone specific for p190 minor bcr-abl fusion peptide

被引：6
|
作者：
Tanaka, Y
Takahashi, T
Nieda, M
Masuda, S
Kashiwase, K
Takahashi, T
Ogawa, S
Chiba, S
Juji, T
Hirai, H
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Hematol & Oncol, Bunkyo Ku, Tokyo 1138655, Japan
[2] Japanese Red Cross Cent Blood Ctr, Tokyo, Japan
来源：
LEUKEMIA RESEARCH | 2002年 / 26卷 / 03期
关键词：
Philadelphia chromosome-positive acute lymphoblastic leukemia; minor BCR/ABL; CTL;
D O I：
10.1016/S0145-2126(01)00119-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In the majority of Ph + ALL patients, p190 bcr-abl fusion protein is generated in the Philadelphia chromosome. The fusion protein may serve as a leukemia antigen because it is not expressed in normal cells and hardly in any other malignancy. From a healthy donor, we have established a p190 bcr-abl fusion peptide-specific CD4+ cytotoxic T-cell clone, activation of which depends on HLA-DRB1*1501. This T-cell clone has a strong cytotoxic activity against autologus MoDCs pulsed with ela2 peptide and its cytotoxicity is not mediated by Fas/Fas ligand or perforin pathway. Success in establishment of the p190 bcr-abl fusion peptide-specific T-cell clone encourages us to develop a new approach to an effective immunotherapy for Ph + ALL. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：317 / 321
页数：5
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