Generation of Fas-independent CD4+cytotoxic T-cell clone specific for p190 minor bcr-abl fusion peptide

被引：6

作者：

Tanaka, Y

Takahashi, T

Nieda, M

Masuda, S

Kashiwase, K

Takahashi, T

Ogawa, S

Chiba, S

Juji, T

Hirai, H

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Hematol & Oncol, Bunkyo Ku, Tokyo 1138655, Japan

[2] Japanese Red Cross Cent Blood Ctr, Tokyo, Japan

来源：

LEUKEMIA RESEARCH | 2002年 / 26卷 / 03期

关键词：

Philadelphia chromosome-positive acute lymphoblastic leukemia; minor BCR/ABL; CTL;

D O I：

10.1016/S0145-2126(01)00119-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the majority of Ph + ALL patients, p190 bcr-abl fusion protein is generated in the Philadelphia chromosome. The fusion protein may serve as a leukemia antigen because it is not expressed in normal cells and hardly in any other malignancy. From a healthy donor, we have established a p190 bcr-abl fusion peptide-specific CD4+ cytotoxic T-cell clone, activation of which depends on HLA-DRB1*1501. This T-cell clone has a strong cytotoxic activity against autologus MoDCs pulsed with ela2 peptide and its cytotoxicity is not mediated by Fas/Fas ligand or perforin pathway. Success in establishment of the p190 bcr-abl fusion peptide-specific T-cell clone encourages us to develop a new approach to an effective immunotherapy for Ph + ALL. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：317 / 321

页数：5

共 49 条

[1] Generation of HLA-DRB1*1501-restricted p190 minor bcr-abl (ela2)-specific CD4+ T lymphocytes
Tanaka, Y
Takahashi, T
Nieda, M
Masuda, S
Kashiwase, K
Ogawa, S
Chiba, S
Juji, T
Hirai, H
BRITISH JOURNAL OF HAEMATOLOGY, 2000, 109 (02) : 435 - 437
[2] Transduction of dendritic cells with the p190 Bcr-Abl oncogene elicits autologous T cell proliferation.
Gruber, TA
Kohn, DB
BLOOD, 2001, 98 (11) : 564A - 564A
[3] BCR-ABL fusion regions as a source of multiple leukemia-specific CD8+ T-cell epitopes
J H Kessler
S A Bres-Vloemans
P A van Veelen
A de Ru
I J G Huijbers
M Camps
A Mulder
R Offringa
J W Drijfhout
O C Leeksma
F Ossendorp
C J M Melief
Leukemia, 2006, 20 : 1738 - 1750
[4] BCR-ABL fusion regions as a source of multiple leukemia-specific CD8+ T-cell epitopes
Kessler, J. H.
Bres-Vloemans, S. A.
van Veelen, P. A.
de Ru, A.
Huijbers, I. J. G.
Camps, M.
Mulder, A.
Offringa, R.
Drijfhout, J. W.
Leeksma, O. C.
Ossendorp, F.
Melief, C. J. M.
LEUKEMIA, 2006, 20 (10) : 1738 - 1750
[5] Interferon gamma downregulates responses of BCR-ABL peptide specific CD4 plus T cells to BCR-ABL positive CML blasts
tenBosch, GJA
Joosten, AM
Melief, CJM
Leeksma, OC
BRITISH JOURNAL OF HAEMATOLOGY, 1996, 93 : 592 - 592
[6] Fas-independent and nonapoptotic cytotoxicity mediated by a human CD4+ T-cell clone directed against an acute myelogenous leukemia-associated DEK-CAN fusion peptide
Ohminami, H
Yasukawa, M
Kaneko, S
Yakushijin, Y
Abe, Y
Kasahara, Y
Ishida, Y
Fujita, S
BLOOD, 1999, 93 (03) : 925 - 935
[7] Fas-independent cytotoxicity mediated by virus-specific human CD4+ cytotoxic T-lymphocytes.
Yasukawa, M
Ohminami, H
Yakushijin, Y
Arai, J
Hasegawa, A
Fujita, S
BLOOD, 1998, 92 (10) : 64B - 64B
[8] A BCR-ABL(p190) fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product
Castellanos, A
Pintado, B
Weruaga, E
Arevalo, R
Lopez, A
Orfao, A
SanchezGarcia, I
BLOOD, 1997, 90 (06) : 2168 - 2174
[9] T-cell blast crisis of chronic myelogenous leukemia presented with coexisting p210 and p190 BCR-ABL transcripts and t(10;11)(q11;p15)
Xia, Ting
Yang, Yuchao
Li, Guoxia
Chang, Jianmei
Li, Jianlan
Ren, Fanggang
Ren, Weixiao
Wang, Hongwei
Xu, Zhifang
JOURNAL OF CLINICAL LABORATORY ANALYSIS, 2020, 34 (06)
[10] Inhibition of growth of a Philadelphia-chromosome positive acute lymphoblastic leukemia cell line by antisense oligonucleotides specific for the p190 bcr-abl oncogene
Snyder, DS
Wu, Y
McMahon, R
Forman, SJ
BLOOD, 1995, 86 (10) : 2956 - 2956

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