Diminished IL-2 responsiveness and FOXP3 expression in T1D subjects is revealed by a disease-associated variant of PTPN2

被引：0
|
作者：
Long, Sarah Alice [1 ]
Bollyky, Paul [1 ]
Cerosaletti, Karen [1 ]
Shilling, Heather [1 ]
Pihoker, Catherine [2 ]
Sanda, Srinath [3 ]
Greenbaum, Carla [3 ]
Buckner, Jane [1 ]
机构：
[1] Benaroya Res Inst, Translat Res, Seattle, WA USA
[2] Childrens Hosp & Reg Med Ctr, Seattle, WA USA
[3] Benaroya Res Inst, Diabet Res, Seattle, WA USA
来源：
JOURNAL OF IMMUNOLOGY | 2009年 / 182卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
49.1
引用
收藏
页数：1
相关论文
共 50 条
  • [21] FOXP3 COOPERATES WITH LINKER HISTONE H1b TO REPRESS IL-2
    Mackey-Cushman, Stephanie
    Su, Lishan
    JOURNAL OF IMMUNOLOGY, 2007, 178
  • [22] An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells
    S A Long
    K Cerosaletti
    J Y Wan
    J-C Ho
    M Tatum
    S Wei
    H G Shilling
    J H Buckner
    Genes & Immunity, 2011, 12 : 116 - 125
  • [23] An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells
    Long, S. A.
    Cerosaletti, K.
    Wan, J. Y.
    Ho, J-C
    Tatum, M.
    Wei, S.
    Shilling, H. G.
    Buckner, J. H.
    GENES AND IMMUNITY, 2011, 12 (02) : 116 - 125
  • [24] IL2 signaling and Foxp1 expression maintain Treg identity in the absence of Foxp3
    Hill, Charlotte Nicole
    Zhong, Yuelin
    Zemmour, David
    Charbonnier, Louis-Marie
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
  • [25] Resolving Early Signaling Events in T-Cell Activation Leading to IL-2 and FOXP3 Transcription
    Perley, Jeffrey P.
    Mikolajczak, Judith
    Buzzard, Gregery T.
    Harrison, Marietta L.
    Rundell, Ann E.
    PROCESSES, 2014, 2 (04): : 867 - 900
  • [26] Foxp3 binds to the endogenous IL-2 and IFNgamma loci in T cells and promotes local histone deacetylation
    Chen, Chunxia
    Rowell, Emily
    Thomas, Rajan
    Wells, Andrew
    JOURNAL OF IMMUNOLOGY, 2006, 176 : S180 - S180
  • [27] Defects in IL-2R Signaling Contribute to Diminished Maintenance of FOXP3 Expression in CD4+ CD25+ Regulatory T-Cells of Type 1 Diabetic Subjects
    Long, S. Alice
    Cerosaletti, Karen
    Bollyky, Paul L.
    Tatum, Megan
    Shilling, Heather
    Zhang, Sheng
    Zhang, Zhong-Yin
    Pihoker, Catherine
    Sanda, Srinath
    Greenbaum, Carla
    Buckner, Jane H.
    DIABETES, 2010, 59 (02) : 407 - 415
  • [28] IL-2 expression in activated human memory FOXP3+ cells critically depends on the cellular levels of FOXP3 as well as of four transcription factors of T cell activation
    Bendfeldt, Hanna
    Benary, Manuela
    Scheel, Tobias
    Steinbrink, Kerstin
    Radbruch, Andreas
    Herzel, Hanspeter
    Baumgrass, Ria
    FRONTIERS IN IMMUNOLOGY, 2012, 3
  • [29] Differential expression and significance of Foxp3,TGF-β1 and IL-2 in peripheral blood of patients with coal-burning arsenic poisoning
    方晓琳
    China Medical Abstracts(Internal Medicine), 2019, 36 (02) : 77 - 78
  • [30] IL2R signaling and Foxp1 expression maintain Treg cell identity in the absence of Foxp3
    Charbonnier, Louis-Marie
    Hill, Charlotte
    Zhong, Yuelin
    Zemmour, David
    JOURNAL OF IMMUNOLOGY, 2024, 212 (01):
12345