Sequence-based typing characterization of the novel HLA-Cw*0340 allele in a Chinese individual

被引：3
|
作者：
Cheng, L. -H. [1 ]
Li, Z. [1 ]
Jin, S. -Z. [1 ]
Zou, H. -Y. [1 ]
机构：
[1] Shenzhen Blood Ctr, Shenzhen Inst Transfus Med, Immunogenet Lab, Shenzhen 518035, Guangdong, Peoples R China
来源：
TISSUE ANTIGENS | 2008年 / 72卷 / 05期
关键词：
human leukocyte antigen-Cw*0340; new allele; sequence-based typing;
D O I：
10.1111/j.1399-0039.2008.01117.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The novel human leukocyte antigen (HLA)-Cw*0340 allele was identified by sequence-based typing in a Chinese individual. This allele shows that the sequences of exons 2-3 of HLA-Cw*0340 are identical to those of HLA-Cw*0302, except for a nucleotide substitution that changes CTC to ATC at codon 95, resulting in an amino acid change from Leu to lle in the protein; this allele also shows that the sequences of exons 2-3 of HLA-Cw*0340 are identical to those of HLA-Cw*030401 or HLA-Cw*030403, except for a nucleotide substitution that changes TAC to TCC at codon 116, resulting in an amino acid change from Try to Ser in the protein.
引用
收藏
页码：495 / 497
页数：3
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