An efficient synthesis of 6-benzyl-2-arylthieno[2,3-d]pyrimidin-4(3H)-ones catalyzed byHClinvolving aFriedel-Craftsalkylation reaction

被引：0

作者：

Pan, Wan-Chen ^{[1
]}

Wang, Yi-Chun ^{[1
]}

Li, Tuan-Jie ^{[1
]}

Liu, Jian-Quan ^{[1
]}

Wang, Xiang-Shan ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Jiangsu Key Lab Green Synth Funct Mat, Sch Chem & Mat Sci, Xuzhou 221116, Jiangsu, Peoples R China

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2020年 / 57卷 / 11期

关键词：

AQUEOUS-MEDIA; DERIVATIVES; ANTICANCER; APOPTOSIS; IODINE; HETEROCYCLES; ALKYLATION; COMPONENTS; INHIBITORS; DISCOVERY;

D O I：

10.1002/jhet.4107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aldehyde could undergo not only the subsequent condensation and cyclization with 2-aminothiophene-3-carboxamide to build a pyrimidine ring, but also a Friedel-Crafts alkylation reaction with thiophene moiety to give unexpected 6-benzyl-2-arylthieno[2,3-d]pyrimidin-4(3H)- ones in good yields catalyzed by concentrated HCl.

引用

页码：3970 / 3979

页数：10

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