Nickel-catalyzed three-component [3+2+2] cocyclization of ethyl cyclopropylideneacetate and alkynes - Selective synthesis of multisubstituted cycloheptadienes

被引：109
|
作者：
Komagawa, S [1 ]
Saito, S [1 ]
机构：
[1] Tokyo Univ Sci, Dept Chem, Tokyo 1628601, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 15期
关键词：
alkynes; cycloaddition; cycloheptadienes; nickel; synthetic methods;
D O I：
10.1002/anie.200504050
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Ménage à trois: Seven-membered carbocycles are formed by the three-component [3+2+2] cycloaddition of ethyl cyclopropylideneacetate and two different alkynes in the presence of a Ni 0/PPh3 catalyst (see scheme). In this one-pot reaction, a highly chemo- and regioselective coupling proceeds, and the cycloheptadiene derivatives are isolated as single isomers. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2446 / 2449
页数：4
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