Four new cycloartane glycosides from Thalictrum fortunei

Four new cycloartane glycosides were isolated from the aerial parts of Thalictrum fortunei (Ranunculaceae). The chemical structures of these new glycosides were elucidated as 3-O-beta-o-glucopyranosyl-(1 -> 4)-beta-D-fucopyranosyl (22S,24Z)-cycloart-24-en-3 beta,22,26-triol 26-O-beta-D-glucopyranoside, 3-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-fucopyranosyl (22S,24Z)-cycloart-24-en-3 beta,22,26-triol 26-O-beta-D-quinovopyranosyl-(1 -> 6)-beta-D-glucopyranoside, 3-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-fucopyranosyl (22S,24Z)-cycloart-24-en-beta,22,26-triol 26-O-beta-D-xylopyranosyl(1 -> 6)-beta-D-glucopyranoside, and 3-O-beta-o-glucopyranosyl-(1 -> 4)-beta-D-fucopyranosyl (22S,24Z)-cycloart-24-en-3 beta,22,26-triol 26-O-alpha-L-arabinopyranosyl-(1 -> 6)-beta-D-glucopyranoside by extensive NMR methods, HR-ESI-MS, and hydrolysis. This is the first report of (22S,24Z)-3 beta,22,26-trihydroxycycloartan-24-ene (thelictogenin A, 5) 14 being glycosylated at C-26.