The diverse expression of the WT1 gene in patients with acquired bone marrow failure syndromes

被引：2
|
作者：
You, Yahong [1 ]
Huo, Jiali [1 ]
Lu, Shihong [1 ]
Shao, Yingqi [1 ]
Ge, Meili [1 ]
Shi, Jun [1 ]
Li, Xingxin [1 ]
Huang, Jinbo [1 ]
Huang, Zhendong [1 ]
Zhang, Jing [1 ]
Wang, Min [1 ]
Nie, Neng [1 ]
Zheng, Yizhou [1 ]
机构：
[1] Chinese Acad Med Sci, Inst Hematol & Blood Dis Hosp, State Key Lab Expt Hematol, 288 Nanjing Rd, Tianjin 300020, Peoples R China
来源：
LEUKEMIA & LYMPHOMA | 2018年 / 59卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Anemia; aplastic; bone marrow failure; WT1; WILMS-TUMOR GENE; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; HYPOPLASTIC MYELODYSPLASTIC SYNDROME; HEMATOPOIETIC PROGENITOR CELLS; MYELOID-LEUKEMIA PATIENTS; APLASTIC-ANEMIA; PERIPHERAL-BLOOD; RESIDUAL DISEASE; MESSENGER-RNA; DIAGNOSIS;
D O I：
10.1080/10428194.2017.1352092
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acquired bone marrow failure syndromes (aBMFS) encompass a wide range of diseases. A study to investigate WT1 expression in BM was conducted in 387 patients with aBMFS in China. The WT1 level in patients with aplastic anemia (AA) was significantly lower than that in patients with paroxysmal nocturnal hemoglobinuria (PNH, p=.023) and myelodysplastic syndrome (MDS, p<.001). In addition, the WT1 level in patients with MDS significantly increased as the disease progressed to an advanced stage. Patients with hypoplastic MDS had a differentiated expression level of WT1 compared with that of NSAA (p<.001). Furthermore, post-treatment patients of AA with partial response (PR) or complete response (CR) status had relatively higher WT1 levels than those with naive AA (p=.017, p=.003, respectively). Thus, the WT1 expression level could be a useful genetic marker for routine clinical work in aBMFS.
引用
收藏
页码：950 / 957
页数：8
相关论文
共 50 条
  • [21] wt1 gene expression in childhood leukemias
    Niegemann, E
    Wehner, S
    Kornhuber, B
    Schwabe, D
    Ebener, U
    ACTA HAEMATOLOGICA, 1999, 102 (02) : 72 - 76
  • [22] Clinical usefulness of WT1 mRNA expression in bone marrow detected by a new WT1 mRNA assay kit for monitoring acute myeloid leukemia: a comparison with expression of WT1 mRNA in peripheral blood
    Kunio Kitamura
    Takahiro Nishiyama
    Ken Ishiyama
    Shuichi Miyawaki
    Kanji Miyazaki
    Kenshi Suzuki
    Hiroaki Masaie
    Masaya Okada
    Hiroyasu Ogawa
    Kiyotoshi Imai
    Hitoshi Kiyoi
    Tomoki Naoe
    Yasuhisa Yokoyama
    Shigeru Chiba
    Tomoko Hata
    Yasushi Miyazaki
    Yoshihiro Hatta
    Jin Takeuchi
    Yasuhito Nannya
    Mineo Kurokawa
    Yasunori Ueda
    Daisuke Koga
    Haruo Sugiyama
    Fumimaro Takaku
    International Journal of Hematology, 2016, 103 : 53 - 62
  • [23] EVALUATION OF PROGNOSTIC UTILITY OF WT1 EXPRESSION IN MIELODYSPLASTIC SYNDROMES
    Introcaso, T.
    Coluzzi, S.
    Gioia, G.
    Nuccorini, R.
    Pascale, S. P.
    Iallorenzi, G.
    Filardi, N. B.
    Chiacchio, R.
    Amendola, A.
    Attolico, I.
    Cimminiello, M.
    Matturro, A.
    Vertone, D.
    Pizzuti, M.
    HAEMATOLOGICA, 2017, 102 : 57 - 58
  • [24] THE GENOMIC ORGANIZATION AND EXPRESSION OF THE WT1 GENE
    GESSLER, M
    KONIG, A
    BRUNS, GAP
    GENOMICS, 1992, 12 (04) : 807 - 813
  • [25] Identification of TINF2 gene mutations in adult Japanese patients with acquired bone marrow failure syndromes
    Yamaguchi, Hiroki
    Inokuchi, Koiti
    Takeuchi, Junko
    Tamai, Hayato
    Mitamura, Yoshio
    Kosaka, Fumiko
    Ly, Hinh
    Dan, Kazuo
    BRITISH JOURNAL OF HAEMATOLOGY, 2010, 150 (06) : 725 - 727
  • [26] No significant expression of Wt1 gene in multiple myeloma patients at diagnosis: Is Wt1 gene expression useful marker for minimal residual disease in multiple myeloma?
    Ozkul, Yusuf
    Caglayan, Ahmet O.
    Kocyigit, Ismail
    Saatci, Cetin
    Akalin, Hilal
    Demir, Muzaffer
    Altuntas, Fevzi
    Cetin, Mustafa
    Eser, Bulent
    Kaynar, Leylagul
    BLOOD, 2007, 110 (11) : 263B - 263B
  • [27] Normal Blood and Bone Marrow Wt1 Expression Level in Extramedullary Relapse in AML Patient
    Girshova, Larisa
    Romanova, Ekaterina
    Gorunova, Elena
    Kholopova, Irina
    Nikulina, Tatiana
    Mirolubova, Julia
    Ivanov, Vladimir
    Zaritskey, Andrey
    BLOOD, 2012, 120 (21)
  • [28] Low level of serum haptoglobin in patients with acquired bone marrow failure (BMF) syndromes
    Ikeda, Kazuhiko
    Takahashi, Naoto
    Kameoka, Junichi
    Tajima, Katsushi
    Murai, Kazunori
    Tamai, Yoshiko
    Noji, Hideyoshi
    Ishida, Yoji
    Sawada, Ken-Ichi
    Shichishima, Tsutomu
    BLOOD, 2007, 110 (11) : 10B - 10B
  • [29] DOUBLE CORD BLOOD TRANSPLANTATION FOR PATIENTS WITH INHERITED AND ACQUIRED BONE MARROW FAILURE SYNDROMES
    Ruggeri, A.
    de Latour, R. Peffault
    Rocha, V.
    Rodrigues, C. A.
    Robin, M.
    Larghero, J.
    Traineau, R.
    Ribaud, P.
    Ferry, C.
    Devergie, A.
    Gluckman, E.
    Socie, G.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 189 - 189
  • [30] Expression of WT1 induces differentiation of committed primary mouse bone marrow cells.
    Menke, AL
    Knops, GHJ
    Linssen, PCM
    Vierwinden, G
    de Witte, T
    van der Reijden, BA
    Janssen, JH
    BLOOD, 2003, 102 (11) : 857A - 857A
12345