The diverse expression of the WT1 gene in patients with acquired bone marrow failure syndromes

被引：2
|
作者：
You, Yahong [1 ]
Huo, Jiali [1 ]
Lu, Shihong [1 ]
Shao, Yingqi [1 ]
Ge, Meili [1 ]
Shi, Jun [1 ]
Li, Xingxin [1 ]
Huang, Jinbo [1 ]
Huang, Zhendong [1 ]
Zhang, Jing [1 ]
Wang, Min [1 ]
Nie, Neng [1 ]
Zheng, Yizhou [1 ]
机构：
[1] Chinese Acad Med Sci, Inst Hematol & Blood Dis Hosp, State Key Lab Expt Hematol, 288 Nanjing Rd, Tianjin 300020, Peoples R China
来源：
LEUKEMIA & LYMPHOMA | 2018年 / 59卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Anemia; aplastic; bone marrow failure; WT1; WILMS-TUMOR GENE; PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA; HYPOPLASTIC MYELODYSPLASTIC SYNDROME; HEMATOPOIETIC PROGENITOR CELLS; MYELOID-LEUKEMIA PATIENTS; APLASTIC-ANEMIA; PERIPHERAL-BLOOD; RESIDUAL DISEASE; MESSENGER-RNA; DIAGNOSIS;
D O I：
10.1080/10428194.2017.1352092
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Acquired bone marrow failure syndromes (aBMFS) encompass a wide range of diseases. A study to investigate WT1 expression in BM was conducted in 387 patients with aBMFS in China. The WT1 level in patients with aplastic anemia (AA) was significantly lower than that in patients with paroxysmal nocturnal hemoglobinuria (PNH, p=.023) and myelodysplastic syndrome (MDS, p<.001). In addition, the WT1 level in patients with MDS significantly increased as the disease progressed to an advanced stage. Patients with hypoplastic MDS had a differentiated expression level of WT1 compared with that of NSAA (p<.001). Furthermore, post-treatment patients of AA with partial response (PR) or complete response (CR) status had relatively higher WT1 levels than those with naive AA (p=.017, p=.003, respectively). Thus, the WT1 expression level could be a useful genetic marker for routine clinical work in aBMFS.
引用
收藏
页码：950 / 957
页数：8
相关论文
共 50 条
  • [1] WT1 expression in patients with myelodysplastic syndromes
    Polistina, M. T.
    Tiberio, C.
    Sagristani, M.
    Esposito, M.
    Improta, S.
    Lucania, A.
    Villa, M. R.
    Mastrullo, L.
    LEUKEMIA RESEARCH, 2007, 31 : S75 - S76
  • [2] Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes
    Ueda, Yasunori
    Mizutani, Chisato
    Nannya, Yasuhito
    Kurokawa, Mineo
    Kobayashi, Sumiko
    Takeuchi, Jin
    Tamura, Hideto
    Ogata, Kiyoyuki
    Dan, Kazuo
    Shibayama, Hirohiko
    Kanakura, Yuzuru
    Niimi, Keiko
    Sasaki, Ko
    Watanabe, Masato
    Emi, Nobuhiko
    Teramura, Masanao
    Motoji, Toshiko
    Kida, Michiko
    Usuki, Kensuke
    Takada, Satoru
    Sakura, Toru
    Ito, Yoshikazu
    Ohyashiki, Kazuma
    Ogawa, Hiroyasu
    Suzuki, Takahiro
    Ozawa, Keiya
    Imai, Kiyotoshi
    Kasai, Masaharu
    Hata, Tomoko
    Miyazaki, Yasushi
    Morita, Yasuyoshi
    Kanamaru, Akihisa
    Matsuda, Akira
    Tohyama, Kaoru
    Koga, Daisuke
    Tamaki, Hiroya
    Mitani, Kinuko
    Naoe, Tomoki
    Sugiyama, Haruo
    Takaku, Fumimaro
    LEUKEMIA & LYMPHOMA, 2013, 54 (07) : 1450 - 1458
  • [3] Wt1 expression and clinical outcome in patients with myelodysplastic syndromes
    Villa, M. R.
    Esposito, M.
    Improta, S.
    Lucania, A.
    Sagristani, M.
    Latte, A.
    Polistina, M. T.
    Mastrullo, T.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 160 - 160
  • [4] Prognostic Significance of WT1 and PRAME Gene Expression in Bone Marrow Samples of MDS and AML Patients Treated with Azacytidine
    Andrews, Claire N.
    Murphy, Karen
    Moran, Sinead
    Thornton, Patrick
    Harten, Nichola
    Murphy, Philip T.
    BLOOD, 2014, 124 (21)
  • [5] Expression of WT1 gene in multiple myeloma patients at diagnosis: is WT1 gene expression a useful marker in multiple myeloma?
    Saatci, Cetin
    Caglayan, A. Okay
    Kocyigit, Ismail
    Akalin, Hilal
    Kaynar, Leyla G.
    Altuntas, Fevzi
    Eser, Bulent
    Demir, Muzaffer
    Cetin, Mustafa
    Ozkul, Yusuf
    HEMATOLOGY, 2010, 15 (01) : 39 - 42
  • [6] WT1 AND CXCR4 EXPRESSION IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES
    Improta, I. S.
    Villa, M. R.
    Lucania, A.
    Esposito, M. R.
    Sagristani, M.
    Pepe, N.
    Rotondo, P.
    Sansone, M.
    Polistina, M. T.
    Mastrullo, L.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 : 276 - 276
  • [7] WT1 AND CXCR4 EXPRESSION IN PATIENTS WITH MYELODYSPLASTIC SYNDROMES
    Improta, S.
    Villa, M. R.
    Lucania, A.
    Esposito, M.
    Russolillo, S.
    Tiberio, C.
    Mostarda, I
    Polistina, M. T.
    Mastrullo, L.
    HAEMATOLOGICA, 2008, 93 : S78 - S78
  • [8] EXPRESSION OF THE TUMOR-SUPPRESSOR GENE WT1 IN BOTH HUMAN AND MOUSE BONE-MARROW
    FRAIZER, GC
    PATMASIRIWAT, P
    ZHANG, XH
    SAUNDERS, GF
    BLOOD, 1995, 86 (12) : 4704 - 4706
  • [9] Serum Level of WT1 Gene Protein and WT1 Gene Expression in Ovarian Cancer
    Dubey, Harshita
    Ranjan, Amar
    Tanwar, Pranay
    JOURNAL OF MOLECULAR DIAGNOSTICS, 2024, 26 (06): : S55 - S55
  • [10] Mutation analysis of the WT1 gene in myelodysplastic syndromes
    Hosoya, N
    Miyagawa, K
    Mitani, K
    Yazaki, Y
    Hirai, H
    JAPANESE JOURNAL OF CANCER RESEARCH, 1998, 89 (08): : 821 - 824
12345