The expression of C-FABP and PPARγ and their prognostic significance in prostate cancer

被引:59
|
作者
Forootan, Farzad S. [1 ]
Forootan, Shiva S. [1 ]
Malki, Mohammed I. [1 ]
Chen, Danqing [1 ]
Li, Gandi [3 ]
Lin, Ke [1 ]
Rudland, Philip S. [2 ]
Foster, Christopher S. [1 ]
Ke, Youqiang [1 ]
机构
[1] Univ Liverpool, Dept Mol & Clin Canc Med, Mol Pathol Lab, Liverpool L69 3GA, Merseyside, England
[2] Univ Liverpool, Dept Biochem & Cell Biol, Liverpool L69 3GA, Merseyside, England
[3] Sichuan Univ, Dept Pathol, West China Hosp, West China Med Sch, Chengdu, Peoples R China
关键词
prostate cancer; C-FABP; PPAR; prognostic factor; ACID-BINDING-PROTEIN; PROLIFERATOR-ACTIVATED RECEPTORS; SQUAMOUS-CELL CARCINOMAS; BREAST-CANCER; LIPID-METABOLISM; POOR SURVIVAL; DIFFERENTIAL EXPRESSION; MESSENGER-RNA; FATTY-ACIDS; GENE;
D O I
10.3892/ijo.2013.2166
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The purpose of this study was to test the hypothesis that cooperative interaction between cutaneous fatty acid-binding protein (C-FABP) and peroxisome proliferator-activated receptors (PPAR) promotes the malignant progression of human prostate cancer. The expression of C-FABP, PPAR/ and PPAR was measured by western blot analysis in prostate cell lines and by immunohistochemical staining in tissue sections of benign prostatic hyperplasia (BPH) and prostatic carcinomas. The correlation between the expression of PPARs and C-FABP was assessed. The significance of increased expression of these proteins was analysed with respect to prognosis and compared with those of alternative biomarkers. The expression levels of C-FABP and PPAR in prostate cancer cell lines and the cytoplasm and nuclei of carcinoma tissues were significantly (Student's t-test, p<0.05) higher compared to those in benign cell lines and BPH tissues. The raised expression level of C-FABP and PPAR was significantly correlated with the increased combined Gleason scores (GS) of the carcinomas. Enhanced expression of cytoplasmic C-FABP significantly correlated with increased nuclear PPAR (Student's t-test, p<0.005). While expression of PPAR/ in carcinomas did not correlate with patient outcome, the increased levels of both C-FABP and PPAR were associated with shorter patient survival. Multivariate analysis indicated that C-FABP was independently associated with patient survival, whereas PPAR was confounded by C-FABP in predicting patient survival. Thus, the increased C-FABP may interact with PPAR in a coordinated mechanism to facilitate malignant progression in prostatic cancer. Both C-FABP and PPAR are suitable as prognostic factors to predict the clinical outcome of prostatic cancer patients.
引用
收藏
页码:265 / 275
页数:11
相关论文
共 50 条
  • [31] Expression and prognostic significance of ELL-associated factor 2 in human prostate cancer
    Zang, Yachen
    Dong, Yun
    Yang, Dongrong
    Xue, Boxin
    Li, Feng
    Gu, Peng
    Zhao, Haifeng
    Wang, Shaoxiong
    Zhou, Songlin
    Ying, Rong
    Wang, Zhou
    Shan, Yuxi
    INTERNATIONAL UROLOGY AND NEPHROLOGY, 2016, 48 (05) : 695 - 700
  • [32] Prognostic significance of thymidylate synthase expression in patients with prostate cancer undergoing radical prostatectomy
    Li, Yongnan
    Mizutani, Yoichi
    Shiraishi, Takumi
    Okihara, Koji
    Ukimura, Osamu
    Kawauchi, Akihiro
    Nonomura, Norio
    Fukushima, Masakazu
    Sakai, Toshiyuki
    Miki, Tsuneharu
    UROLOGY, 2007, 69 (05) : 988 - 995
  • [33] Expression and prognostic significance of ELL-associated factor 2 in human prostate cancer
    Yachen Zang
    Yun Dong
    Dongrong Yang
    Boxin Xue
    Feng Li
    Peng Gu
    Haifeng Zhao
    Shaoxiong Wang
    Songlin Zhou
    Rong Ying
    Zhou Wang
    Yuxi Shan
    International Urology and Nephrology, 2016, 48 : 695 - 700
  • [34] Prognostic significance of neuroendocrine differentiation, proliferation activity and androgen receptor expression in prostate cancer
    Segawa, N
    Mori, I
    Utsunomiya, H
    Nakamura, M
    Nakamura, Y
    Shan, L
    Kakudo, K
    Katsuoka, Y
    PATHOLOGY INTERNATIONAL, 2001, 51 (06) : 452 - 459
  • [35] The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer
    Hu, Jianxin
    Luo, Heng
    Xu, Yuangao
    Luo, Guangheng
    Xu, Shuxiong
    Zhu, Jianguo
    Song, Dalong
    Sun, Zhaolin
    Kuang, Youlin
    CANCER INVESTIGATION, 2019, 37 (4-5) : 199 - 208
  • [36] Clinical and prognostic significance of Arl4c expression in colorectal cancer
    Chen, Xiaobo
    Su, Zhaoliang
    Wang, Shengjun
    Xu, Huaxi
    CANCER BIOMARKERS, 2016, 16 (02) : 253 - 257
  • [37] Prognostic significance of tenascin-C expression in superficial and invasive bladder cancer
    Brunner, A
    Mayerl, C
    Tzankov, A
    Verdorfer, I
    Tschörner, I
    Rogatsch, H
    Mikuz, G
    JOURNAL OF CLINICAL PATHOLOGY, 2004, 57 (09) : 927 - 931
  • [38] The prognostic significance of Gleason scores in metastatic prostate cancer
    Rusthoven, Chad G.
    Carlson, Julie A.
    Waxweiler, Timothy V.
    Yeh, Norman
    Raben, David
    Flaig, Thomas W.
    Kavanagh, Brian D.
    UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2014, 32 (05) : 707 - 713
  • [39] Prognostic significance of perineural invasion in localized prostate cancer
    Lu, Louis
    Singhal, Udit
    Skolarus, Ted A.
    Palapattu, Ganesh S.
    Montgomery, Jeffrey Scott
    Weizer, Alon Z.
    Hollenbeck, Brent K.
    Miller, David Christopher
    McNamara, Alyssa
    Mehra, Rohit
    Tomlins, Scott A.
    Hamstra, Daniel A.
    Morgan, Todd Matthew
    Feng, Felix Yi-Chung
    JOURNAL OF CLINICAL ONCOLOGY, 2015, 33 (07)
  • [40] Significance Analysis of Prognostic Signatures Applied to Prostate Cancer
    Montaser, L.
    Beck, A. H.
    MODERN PATHOLOGY, 2013, 26 : 235A - 235A