The Statistical Properties of Protein Folding in the φ4 Theory

被引:0
|
作者
Januar, M. [1 ]
Sulaiman, A. [2 ]
Handoko, L. T. [1 ,3 ]
机构
[1] Univ Indonesia, Dept Phys, Depok 16424, Indonesia
[2] Badan Pengkajian & Penerapan Teknol, Jakarta 10340, Indonesia
[3] Indonesian Inst Sci, Res Ctr Phys, Grp Theoret & Computat Phys, Tangerang 15310, Indonesia
关键词
Protein Folding; Model; Nonlinear; DYNAMICS;
D O I
10.1166/jctn.2013.3175
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The statistical properties of protein folding within the phi(4) model are investigated. The calculation is performed using statistical mechanics and path integral method. In particular, the evolution of heat capacity in term of temperature is given for various levels of the nonlinearity of source and the strength of interaction between protein backbone and nonlinear source. It is found that the nonlinear source contributes constructively to the specific heat especially at higher temperature when it is weakly interacting with the protein backbone. This indicates increasing energy absorption as the intensity of nonlinear sources are getting greater. The simulation of protein folding dynamics within the model is also refined.
引用
收藏
页码:2106 / 2112
页数:7
相关论文
共 50 条
  • [21] Protein folding: Theory meets disease
    Hunter, P
    SCIENTIST, 2003, 17 (17): : 24 - 27
  • [22] Protein folding: Matching theory and experiment
    Laurents, DV
    Baldwin, RL
    BIOPHYSICAL JOURNAL, 1998, 75 (01) : 428 - 434
  • [23] Experiment and theory agree on protein folding
    不详
    CHEMICAL & ENGINEERING NEWS, 2002, 80 (44) : 30 - 30
  • [24] Protein folding: from theory to practice
    Thirumalai, D.
    Liu, Zhenxing
    O'Brien, Edward P.
    Reddy, Govardhan
    CURRENT OPINION IN STRUCTURAL BIOLOGY, 2013, 23 (01) : 22 - 29
  • [25] Cooperativity in protein folding: theory and experiment
    Chan, H. S.
    BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE, 2010, 88 (02): : 409 - 409
  • [26] DEVELOPMENTS IN THE THEORY OF PROTEIN FOLDING SIMULATIONS
    ROBSON, B
    JOURNAL OF MOLECULAR GRAPHICS, 1988, 6 (04): : 214 - 214
  • [27] Protein folding: Matching theory and experiment
    Mirny, L
    Shakhnovich, EI
    PROTEIN FOLDING, EVOLUTION AND DESIGN, 2001, 333 : 37 - 68
  • [28] On "Levinthal paradox" and the theory of protein folding
    Durup, J
    THEOCHEM-JOURNAL OF MOLECULAR STRUCTURE, 1998, 424 (1-2): : 157 - 169
  • [29] Millisecond Timescale, Atomistic Protein Folding Simulations Yield a Network Theory for Protein Folding
    Bowman, Gregory R.
    Pande, Vijay S.
    BIOPHYSICAL JOURNAL, 2010, 98 (03) : 614A - 614A
  • [30] Statistical mechanics of protein folding with separable energy functions
    Wang, JY
    Crippen, GM
    BIOPOLYMERS, 2004, 74 (03) : 214 - 220