HPV Pathway Profiling: HPV Related Cervical Dysplasia and Carcinoma Studies

被引：0

作者：

Scholl, Susy M. ^{[1
]}

Kamal, Maud ^{[1
]}

De Koning, Leanne ^{[1
]}

Kereszt, Attila ^{[2
]}

Jordanova, Ekaterina S. ^{[3
]}

Ungureanu, Sergiu ^{[4
]}

Berns, Els ^{[5
]}

Sastre, Xavier ^{[1
]}

机构：

[1] Inst Curie, Paris, France

[2] SeqOmics, Szeged, Hungary

[3] Ctr Gyneacol Oncol, Amsterdam, Netherlands

[4] Inst Oncol Moldova, Kishinev, Moldova

[5] Erasmus MC, Rotterdam, Netherlands

来源：

CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 08期

关键词：

Cervical cancer; HPV; vaccines; omics; targeted therapy; SQUAMOUS-CELL CARCINOMA; COLONY-STIMULATING FACTOR; PHASE PROTEIN MICROARRAYS; TUMOR-SUPPRESSOR PROTEIN; HUMAN-PAPILLOMAVIRUS DNA; GROWTH-FACTOR RECEPTOR; IGF-BINDING PROTEIN-3; C-MET; FACTOR-I; CONCURRENT CHEMORADIATION;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cervical cancer is the second most common malignancy among women worldwide. While more than 90% of cervical cancers carry one or more high risk HPV types, the exact relationship between HPV oncoproteins and signaling pathways alterations in cervical cancer remains to be clarified. Vaccines and targeted therapies are today considered of great potential for the improvement of patients' outcome. This review will focus on the interaction of HPV with cervical cancer pathway activations. Next generation high throughput screening technologies for molecular and protein profiling as well as innovative logistics, necessary for the implementation of the personalized care of cervical cancer patients will be discussed.

引用

页码：1379 / 1394

页数：16

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