A Rule-Based Model of Base Excision Repair

被引：0

作者：

Kohler, Agnes ^{[1
]}

Krivine, Jean ^{[2
]}

Vidmar, Jakob ^{[2
]}

机构：

[1] INRIA Rocquencourt, Domaine Voluceau Rocquencourt BP 105, F-78153 Le Chesnay, France

[2] Univ Paris Diderot, Sorbonne Paris Cite, Lab PPS, UMR 7126, F-75205 Paris, France

来源：

COMPUTATIONAL METHODS IN SYSTEMS BIOLOGY, CMSB 2014 | 2014年 / 8859卷

关键词：

DNA-POLYMERASE-BETA; HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE; BINDING; XRCC1; GLYCOSYLASE; SUBSTRATE; CONTACT; STATE;

D O I：

暂无

中图分类号：

TP301 [理论、方法];

学科分类号：

081202 ;

摘要：

There are ongoing debates in the DNA repair community on whether the coordination of DNA repair is achieved by means of direct protein-protein interactions or whether substrate specificity is sufficient to explain how DNA intermediates are channeled from one repair enzyme to the other. In order to address these questions we designed a model of the Base Excision Repair pathway in Kappa, a rule based formalism for modeling protein-protein and protein-DNA interactions. We use this model to shed light on the key role of the scaffolding protein XRCC1 in coordinating the repair process.

引用

页码：173 / 195

页数：23

共 50 条

[21] Rule-based model for visual geometrical illusions
Seki, Kazunori
Sugie, Noboru
Sugihara, Kokichi
[J]. Systems and Computers in Japan, 1988, 19 (11) : 97 - 109
[22] Model refactorings as rule-based update transformations
Porres, I
[J]. UML 2003 - THE UNIFIED MODELING LANGUAGE, PROCEEDINGS: MODELING LANGUAGES AND APPLICATIONS, 2003, 2863 : 159 - 174
[23] A rule-based model of insulin signalling pathway
Di Camillo, Barbara
Carlon, Azzurra
Eduati, Federica
Toffolo, Gianna Maria
[J]. BMC SYSTEMS BIOLOGY, 2016, 10
[24] A RULE-BASED SOFTWARE QUALITY CLASSIFICATION MODEL
Khoshgoftaar, Taghi M.
Bullard, Lofton A.
Gao, Kehan
[J]. INTERNATIONAL JOURNAL OF RELIABILITY QUALITY AND SAFETY ENGINEERING, 2008, 15 (03) : 247 - 259
[25] Rule-based model of bacterial transcription initiation
Sorokin, A.
Temlyakova, E.
[J]. FEBS JOURNAL, 2013, 280 : 569 - 569
[26] A Rule-based Model for Normalization of SMS Text
Khan, Osama A.
Karim, Asim
[J]. 2012 IEEE 24TH INTERNATIONAL CONFERENCE ON TOOLS WITH ARTIFICIAL INTELLIGENCE (ICTAI 2012), VOL 1, 2012, : 634 - 641
[27] A temporal neurofuzzy model for rule-based systems
Alpaslan, FN
Bilen, E
Jain, L
[J]. FIRST INTERNATIONAL CONFERENCE ON KNOWLEDGE-BASED INTELLIGENT ELECTRONIC SYSTEMS, PROCEEDINGS 1997 - KES '97, VOLS 1 AND 2, 1997, : 690 - 695
[28] A rule-based XML access control model
Anutariya, C
Chatvichienchai, S
Iwiahara, M
Wuwongse, V
Kambayashi, Y
[J]. RULES AND RULE MARKUP LANGUAGES FOR THE SEMANTIC WEB, 2003, 2876 : 35 - 48
[29] Generating a hierarchical fuzzy rule-based model
Kerr-Wilson, Jeremy
Pedrycz, Witold
[J]. FUZZY SETS AND SYSTEMS, 2020, 381 : 124 - 139
[30] Rule-Based Model of Vein Graft Remodeling
Hwang, Minki
Garbey, Marc
Berceli, Scott A.
Wu, Rongling
Jiang, Zhihua
Roger Tran-Son-Tay
[J]. PLOS ONE, 2013, 8 (03):

← 1 2 3 4 5 →