A Rule-Based Model of Base Excision Repair

被引：0

作者：

Kohler, Agnes ^{[1
]}

Krivine, Jean ^{[2
]}

Vidmar, Jakob ^{[2
]}

机构：

[1] INRIA Rocquencourt, Domaine Voluceau Rocquencourt BP 105, F-78153 Le Chesnay, France

[2] Univ Paris Diderot, Sorbonne Paris Cite, Lab PPS, UMR 7126, F-75205 Paris, France

来源：

COMPUTATIONAL METHODS IN SYSTEMS BIOLOGY, CMSB 2014 | 2014年 / 8859卷

关键词：

DNA-POLYMERASE-BETA; HUMAN APURINIC/APYRIMIDINIC ENDONUCLEASE; BINDING; XRCC1; GLYCOSYLASE; SUBSTRATE; CONTACT; STATE;

D O I：

暂无

中图分类号：

TP301 [理论、方法];

学科分类号：

081202 ;

摘要：

There are ongoing debates in the DNA repair community on whether the coordination of DNA repair is achieved by means of direct protein-protein interactions or whether substrate specificity is sufficient to explain how DNA intermediates are channeled from one repair enzyme to the other. In order to address these questions we designed a model of the Base Excision Repair pathway in Kappa, a rule based formalism for modeling protein-protein and protein-DNA interactions. We use this model to shed light on the key role of the scaffolding protein XRCC1 in coordinating the repair process.

引用

页码：173 / 195

页数：23

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