Application of Bone Marrow Stem Cell Based Therapy in Bone Loss Diseases

被引：4
|
作者：
Xiao, Nan [1 ]
机构：
[1] Univ Pacific, Arthur A Dugoni Sch Dent, Dept Biomed Sci, San Francisco, CA 94103 USA
来源：
CURRENT PHARMACEUTICAL DESIGN | 2017年 / 23卷 / 41期
关键词：
Bone marrow stem cells; stem cell therapy; osteogenesis; osteoclastogenesis; bone loss diseases; bone repair; COLONY-STIMULATING FACTOR; KAPPA-B LIGAND; OSTEOPOROSIS-RELATED FRACTURES; MESENCHYMAL STROMAL CELLS; MOLECULAR-WEIGHT HEPARINS; TISSUE-ENGINEERED BONE; PARATHYROID-HORMONE; OSTEOGENESIS IMPERFECTA; OSTEOBLAST DIFFERENTIATION; POSTMENOPAUSAL WOMEN;
D O I：
10.2174/1381612823666170601113348
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Hematopoietic bone marrow stem cell transplantation has been regularly used in clinical practice for over 40 years. Further research indicates that bone marrow stromal cells are also stem cells that are capable of self-renewal, proliferation and differentiation. With appropriate induction, the bone marrow stromal cells can differentiate into bone, cartilage, tendon, adipose tissue and fibrous tissue, which would potentially be applied for treating bone loss diseases. This review outlines research in understanding role of bone marrow stem cells and stem cells from other origins in bone repair, and highlight the current and potential stem cell based treatment for bone loss diseases in the future.
引用
收藏
页码：6288 / 6297
页数：10
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