In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject

被引：92
|
作者：
Tsibris, Athe M. N. [1 ,2 ]
Sagar, Manish [2 ,3 ]
Gulick, Roy M. [4 ]
Su, Zhaohui [5 ]
Hughes, Michael [5 ]
Greaves, Wayne [6 ]
Subramanian, Mani
Flexner, Charles [7 ]
Giguel, Francoise [1 ]
Leopold, Kay E. [8 ]
Coakley, Eoin [9 ]
Kuritzkes, Daniel R. [2 ,3 ]
机构：
[1] Massachusetts Gen Hosp, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Brigham & Womens Hosp, Boston, MA 02115 USA
[4] Cornell Univ, Weill Med Coll, New York, NY 10021 USA
[5] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA
[6] Schering Plough Res Inst, Kenilworth, NJ USA
[7] Johns Hopkins Univ, Baltimore, MD USA
[8] Harvard Univ, Cambridge, MA 02138 USA
[9] Monogram Biosci, San Francisco, CA USA
来源：
JOURNAL OF VIROLOGY | 2008年 / 82卷 / 16期
关键词：
D O I：
10.1128/JVI.00444-08
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Little is known about the in vivo development of resistance to human immunodeficiency virus type 1 (HIV-1) CCR5 antagonists. We studied 29 subjects with virologic failure from a phase IIb study of the CCR5 antagonist vicriviroc (VCV) and identified one individual with HIV-1 subtype C who developed VCV resistance. Studies with chimeric envelopes demonstrated that changes within the V3 loop were sufficient to confer VCV resistance. Resistant virus showed VCV-enhanced replication, cross-resistance to another CCR5 antagonist, TAK779, and increased sensitivity to aminooxypentane-RANTES and the CCR5 monoclonal antibody HGS004. Pretreatment V3 loop sequences reemerged following VCV discontinuation, implying that VCV resistance has associated fitness costs.
引用
收藏
页码：8210 / 8214
页数：5
相关论文
共 50 条
  • [41] Quantifying Differences in the Tempo of Human Immunodeficiency Virus Type 1 Subtype Evolution
    Abecasis, Ana B.
    Vandamme, Anne-Mieke
    Lemey, Philippe
    JOURNAL OF VIROLOGY, 2009, 83 (24) : 12917 - 12924
  • [42] Evidence for frequent reinfection with human immunodeficiency virus type 1 of a different subtype
    Chohan, B
    Lavreys, L
    Rainwater, SMJ
    Overbaugh, J
    JOURNAL OF VIROLOGY, 2005, 79 (16) : 10701 - 10708
  • [43] Perinatal transmission of hepatitis C virus from human immunodeficiency virus type 1-infected mothers
    Thomas, DL
    Villano, SA
    Riester, KA
    Hershow, R
    Mofenson, LM
    Landesman, SH
    Hollinger, FB
    Davenny, K
    Riley, L
    Diaz, C
    Tang, HB
    Quinn, TC
    JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (06): : 1480 - 1488
  • [44] Prevalence of Hepatitis C Virus and Human Pegivirus Type 1 Co-Infection in Patients Infected with Human Immunodeficiency Virus Type-1
    Elahimanesh, Zahra
    Bokharaei-Salim, Farah
    Donyavi, Tahereh
    Monavari, Seyed Hamidreza
    Tavakoli, Ahmad
    Khoshmirsafa, Majid
    Chavoshpour, Sara
    Abbasi-Kolli, Mohammad
    Ghalejoogh, Zohreh Yousefi
    Kiani, Seyed Jalal
    VIRAL HEPATIT DERGISI-VIRAL HEPATITIS JOURNAL, 2024, 30 (03): : 53 - 58
  • [45] CpG oligodeoxynucleotides block human immunodeficiency virus type 1 replication in human lymphoid tissue infected ex vivo
    Schlaepfer, E
    Audigé, A
    von Beust, B
    Manolova, V
    Weber, M
    Joller, H
    Bachmann, MF
    Kundig, TM
    Speck, RF
    JOURNAL OF VIROLOGY, 2004, 78 (22) : 12344 - 12354
  • [46] Cytomegalovirus myelitis in a child infected with human immunodeficiency virus type 1
    Marriage, SC
    Booy, R
    Lyall, EGH
    Evans, JA
    Owens, C
    Watkins, RP
    Walters, S
    PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1996, 15 (06) : 549 - 551
  • [47] Development of AIDS in a chimpanzee infected with human immunodeficiency virus type 1
    Novembre, FJ
    Saucier, M
    Anderson, DC
    Klumpp, SA
    ONeill, SP
    Brown, CR
    Hart, CE
    Guenthner, PC
    Swenson, RB
    McClure, HM
    JOURNAL OF VIROLOGY, 1997, 71 (05) : 4086 - 4091
  • [48] Assisted reproduction for couples infected with the human immunodeficiency virus type 1
    Anderson, DJ
    FERTILITY AND STERILITY, 1999, 72 (04) : 592 - 594
  • [49] Diagnosis of neurosyphilis in patients infected with human immunodeficiency virus type 1
    Marra, CM
    Gary, DW
    Kuypers, J
    Jacobson, MA
    JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (01): : 219 - 221
  • [50] Selenium and interleukins in persons infected with human immunodeficiency virus type 1
    Baum, MK
    Miguez-Burbano, MJ
    Campa, A
    Shor-Posner, G
    JOURNAL OF INFECTIOUS DISEASES, 2000, 182 : S69 - S73
12345