Bioluminescence Tomography Improves Quantitative Accuracy for Pre-Clinical Imaging

被引：0

作者：

Guggenheim, James A. ^{[1
]}

Basevi, Hector R. A. ^{[1
]}

Styles, Iain B.

Frampton, Jon

Dehghani, Hamid ^{[1
]}

机构：

[1] Univ Birmingham, Coll Engn & Phys Sci, Phys Sci Imaging Biomed Sci Doctoral Training Ctr, Birmingham B15 2TT, W Midlands, England

来源：

DIFFUSE OPTICAL IMAGING IV | 2013年 / 8799卷

关键词：

RECONSTRUCTION; RESOLUTION;

D O I：

10.1117/12.2033317

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

A study is presented that demonstrates that bioluminescence tomography can reconstruct accurate 3D images of internal light sources placed at a range of depths within a physical phantom and that it provides more reliable quantitative data than standard bioluminescence imaging. Specifically, it is shown that when imaging sources at depths ranging from 5 to 15mm, estimates of total source strength are stable to within +/- 11% using tomography whilst values deduced by traditional methods vary 10-fold. Additionally, the tomographic approach correctly localises sources to within 1.5mm error in all cases considered.

引用

页数：6

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