Bioluminescence Tomography Improves Quantitative Accuracy for Pre-Clinical Imaging

被引：0
|
作者：
Guggenheim, James A. [1 ]
Basevi, Hector R. A. [1 ]
Styles, Iain B.
Frampton, Jon
Dehghani, Hamid [1 ]
机构：
[1] Univ Birmingham, Coll Engn & Phys Sci, Phys Sci Imaging Biomed Sci Doctoral Training Ctr, Birmingham B15 2TT, W Midlands, England
来源：
DIFFUSE OPTICAL IMAGING IV | 2013年 / 8799卷
关键词：
RECONSTRUCTION; RESOLUTION;
D O I：
10.1117/12.2033317
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
A study is presented that demonstrates that bioluminescence tomography can reconstruct accurate 3D images of internal light sources placed at a range of depths within a physical phantom and that it provides more reliable quantitative data than standard bioluminescence imaging. Specifically, it is shown that when imaging sources at depths ranging from 5 to 15mm, estimates of total source strength are stable to within +/- 11% using tomography whilst values deduced by traditional methods vary 10-fold. Additionally, the tomographic approach correctly localises sources to within 1.5mm error in all cases considered.
引用
收藏
页数：6
相关论文
共 50 条
  • [1] Limit of Setup Accuracy Using Bioluminescence Imaging to Guide Focal Pre-Clinical Irradiation
    Wong, J.
    Armour, M.
    Tuli, R.
    Herman, J.
    Artemov, D.
    Patterson, M.
    MEDICAL PHYSICS, 2011, 38 (06)
  • [2] Accounting for filter bandwidth improves the quantitative accuracy of bioluminescence tomography
    Taylor, Shelley L.
    Mason, Suzannah K. G.
    Glinton, Sophie L.
    Cobbold, Mark
    Dehghani, Hamid
    JOURNAL OF BIOMEDICAL OPTICS, 2015, 20 (09)
  • [3] Accuracy of off-line bioluminescence imaging to localize targets in pre-clinical radiation research
    Tuli, Richard
    Armour, Michael
    Surmak, Andrew
    Reyes, Juvenal
    Wong, John
    CANCER RESEARCH, 2012, 72
  • [4] Characterization of a Commercial Bioluminescence Tomography System for Pre-Clinical Radiation Research
    Xu, X.
    Deng, Z.
    Sforza, D.
    Reinhart, A. M.
    Tsouchlos, P.
    Dehghani, H.
    Wong, J. W.
    Wang, K.
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2021, 111 (03): : S96 - S96
  • [5] Mobile bioluminescence tomography-guided system for pre-clinical radiotherapy research
    Deng, Z. I. J. I. A. N.
    Xu, X. I. A. N. G. K. U. N.
    Iordachita, I. U. L. I. A. N.
    Dehghani, H. A. M. I. D.
    Zhang, Bin
    Wong, John W.
    Wang, Ken Kang-Hsin
    Wang, Kang-Hsin
    BIOMEDICAL OPTICS EXPRESS, 2022, 13 (09): : 4970 - 4989
  • [6] Instrumentation and methodology for quantitative pre-clinical imaging studies
    Meikle, SR
    Eberl, S
    Iida, H
    CURRENT PHARMACEUTICAL DESIGN, 2001, 7 (18) : 1945 - 1966
  • [7] A Pre-Clinical Bioluminescence Tomography-Guided Radiation Research Platform for Pancreatic Cancer
    Deng, Z.
    Xu, X.
    Dehghani, H.
    Klose, A.
    Tran, P.
    Wang, K.
    MEDICAL PHYSICS, 2019, 46 (06) : E381 - E382
  • [8] Characterization of a commercial bioluminescence tomography-guided system for pre-clinical radiation research
    Xu, Xiangkun
    Deng, Zijian
    Sforza, Daniel
    Tong, Zhishen
    Tseng, Yu-Pei
    Newman, Ciara
    Reinhart, Merle
    Tsouchlos, Paul
    Devling, Tim
    Dehghani, Hamid
    Iordachita, Iulian
    Wong, John W.
    Wang, Ken Kang-Hsin
    MEDICAL PHYSICS, 2023, 50 (10) : 6433 - 6453
  • [9] Characterization of Bioluminescence Tomography-Guided System (MuriGlo) for Pre-Clinical Radiation Research
    Xu, X.
    Deng, Z.
    Tsouchlos, P.
    Kanesalingam, T.
    Dehghani, H.
    Wong, J.
    Wang, K.
    MEDICAL PHYSICS, 2019, 46 (06) : E489 - E489
  • [10] Self-Supervised Hybrid Neural Network Approach to Achieve Quantitative Bioluminescence Tomography for Pre-Clinical Image-Guided Radiation Research
    Deng, B.
    Tong, Z.
    Xu, X.
    Dehghani, H.
    Wang, K. K. H.
    MEDICAL PHYSICS, 2024, 51 (09) : 6644 - 6645
12345