Nanoparticles Loaded with Platinum Drugs for Colorectal Cancer Therapy

被引：18
|
作者：
Buyana, Buhle [1 ]
Naki, Tobeka [1 ]
Alven, Sibusiso [1 ]
Aderibigbe, Blessing Atim [1 ]
机构：
[1] Univ Ft Hare, Dept Chem, ZA-5700 Alice, Eastern Cape Pr, South Africa
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 19期
基金：
英国医学研究理事会; 新加坡国家研究基金会;
关键词：
colorectal cancer; nanoparticles; platinum; colon; rectum; anticancer drugs; SOLID LIPID NANOPARTICLES; PHASE-II TRIAL; COLON-CANCER; CELLULAR ACCUMULATION; GOLD NANOPARTICLES; FLUOROURACIL-LEUCOVORIN; POLYMERIC NANOPARTICLES; INTRACELLULAR DELIVERY; MULTIDRUG-RESISTANCE; MOLECULAR-MECHANISMS;
D O I：
10.3390/ijms231911261
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Colorectal cancer is a common cancer in both men and women. Numerous studies on the therapeutic effectiveness of nanoparticles against colorectal cancer have been reported. Platinum treatments as well as other medications comprising of nanoparticles have been utilized. Drug resistance restricts the use of platinum medicines, despite their considerable efficacy against a variety of cancers. This review reports clinically licensed platinum medicines (cisplatin, carboplatin, and oxaliplatin) combined with various nanoparticles that have been evaluated for their therapeutic efficacy in the treatment of colorectal cancer, including their mechanism of action, resistance, and limitations.
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页数：22
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