Antimicrobial activities of some newly synthesized substituted Benzosuberone and its related derivatives

被引：0

作者：

Abd El-Salam, Osama I. ^{[1
]}

Alsayed, Ali S. ^{[2
]}

Ali, Korany A. ^{[1
]}

Abd Elwahab, Ahmed A. ^{[1
]}

Amr, Abd El-Galil E. ^{[1
,3
]}

Awad, Ghada E. A. ^{[4
]}

机构：

[1] Natl Res Ctr, Appl Organ Chem Dept, Giza 12622, Egypt

[2] Al Azhar Univ, Chem Dept, Cairo 1435, Egypt

[3] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, Drug Explorat & Dev Chair, Riyadh 11451, Saudi Arabia

[4] Natl Res Ctr, Pharmaceut Ind Div, Chem Nat & Microbial Prod Dept, 33 El Buhouth St, Giza 12622, Egypt

来源：

BIOMEDICAL RESEARCH-INDIA | 2017年 / 28卷 / 01期

关键词：

Substituted benzosuberone; Pyrimidine; Pyrazole; Triazole; Antimicrobial activity; ANTIDEPRESSANT ACTIVITY; SERIES;

D O I：

暂无

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A series of substituted benzosuberone scaffold fused with pyrazole, isoxazole, pyrimidine and triazole moieties were synthesized and evaluated as antimicrobial agents. Some reactions were performed under microwave irradiation, resulted in short time reactions and surprisingly high yields. Some of the obtained products showed remarkable antimicrobial activities and the most active products 7b, 9, 13 and 14 were further tested to evaluate their Minimum Inhibitory Concentration (MIC) value at 125 mu g/mL. The structures of new compounds were proved by their elemental analyses and spectral data.

引用

页码：157 / 163

页数：7

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