Induction of myelin gene expression in Schwann cell cultures by an interleukin-6 receptor-interleukin-6 chimera

被引：22
|
作者：
Haggiag, S [1 ]
Chebath, J [1 ]
Revel, M [1 ]
机构：
[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel
来源：
FEBS LETTERS | 1999年 / 457卷 / 02期
关键词：
myelination; Po protein; myelin basic protein; Schwann cell; interleukin-6; receptor;
D O I：
10.1016/S0014-5793(99)01040-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Expression of myelin basic protein (NLBP) and Po gene products is induced during the final postnatal maturation of Schwann cells and reinduced during nerve regeneration. We show that a chimeric protein containing interleukin-6 fused to its soluble receptor (IL6RIL6 chimera) induces MBP and Po RNAs and proteins in cultures of dorsal root ganglia (DRG) from 14 day old mouse embryos. Activation of gp130 signaling by IL6RIL6 appears comparable to cyclic AMP elevating agents to induce: the myelin gene products in DRG and in pure Schwann cell cultures. (C) 1999 Federation of European Biochemical Societies.
引用
收藏
页码：200 / 204
页数：5
相关论文
共 50 条
  • [21] Interleukin-6, soluble interleukin-6 receptor/interleukin-6 complex and insulin resistance in obese children and adolescents
    G. De Filippo
    D. Rendina
    F. Moccia
    V. Rocco
    A. Campanozzi
    Journal of Endocrinological Investigation, 2015, 38 : 339 - 343
  • [22] SOLUBLE INTERLEUKIN-6 RECEPTOR TRIGGERS OSTEOCLAST FORMATION BY INTERLEUKIN-6
    TAMURA, T
    UDAGAWA, N
    TAKAHASHI, N
    MIYAURA, C
    TANAKA, S
    YAMADA, Y
    KOISHIHARA, Y
    OHSUGI, Y
    KUMAKI, K
    TAGA, T
    KISHIMOTO, T
    SUDA, T
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) : 11924 - 11928
  • [23] Regulation of plasminogen gene expression by interleukin-6
    Jenkins, GR
    Seiffert, D
    Parmer, RJ
    Miles, LA
    BLOOD, 1997, 89 (07) : 2394 - 2403
  • [24] Regulation of interleukin-6 gene expression by steroids
    Ray, A
    Zhang, DH
    Siegel, MD
    Ray, P
    INTERLEUKIN-6 TYPE CYTOKINES, 1995, 762 : 79 - 88
  • [25] Cytomegalovirus modulates interleukin-6 gene expression
    Geist, LJ
    Dai, LY
    TRANSPLANTATION, 1996, 62 (05) : 653 - 658
  • [26] Glucocorticoid-dependent induction of interleukin-6 receptor expression in human hepatocytes facilitates interleukin-6 stimulation of amino acid transport
    Fischer, CP
    Bode, BP
    Takahashi, K
    Tanabe, KK
    Souba, WW
    ANNALS OF SURGERY, 1996, 223 (05) : 610 - 618
  • [27] Induction of myelin gene expression in Schwann cells following upregulation of ZBP-99 by a chimera of IL6 and IL-6-receptor
    Levy, A
    Ainbinder, E
    Slutsky, G
    Adjalley, S
    Zwang, R
    Chebath, J
    Revel, M
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2005, 238 : S190 - S190
  • [28] Interleukin-6, interleukin-6 receptor gene variant, small-vessel disease and incident dementia
    Miwa, K.
    Okazaki, S.
    Sakaguchi, M.
    Mochizuki, H.
    Kitagawa, K.
    EUROPEAN JOURNAL OF NEUROLOGY, 2016, 23 (03) : 656 - 663
  • [29] Induction of myelin gene expression in Schwann cells following upregulation of ZBP-99 by a chimera of IL6 and IL-6-receptor
    Levy, A
    Ainbinder, E
    Shutsky, G
    Adjalley, S
    Zwang, R
    Chebath, J
    Revel, M
    JOURNAL OF THE NEUROLOGICAL SCIENCES, 2005, 238 : S190 - S190
  • [30] Expression of Interleukin-6 and the Interleukin-6 Receptor Predicts the Clinical Outcomes of Patients with Soft Tissue Sarcomas
    Nakamura, Koichi
    Nakamura, Tomoki
    Iino, Takahiro
    Hagi, Tomohito
    Kita, Kouji
    Asanuma, Kunihiro
    Sudo, Akihiro
    CANCERS, 2020, 12 (03)
12345