Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2

被引：34

作者：

Peng, Tao ^{[1
]}

Liu, Xiangpei ^{[1
,2
]}

Adams, L. Garry ^{[1
]}

Agarwal, Girish ^{[1
]}

Akey, Bruce ^{[1
]}

Cirillo, Jeffrey ^{[1
]}

Deckert, Volker ^{[1
,3
,4
]}

Delfan, Sahar ^{[1
]}

Fry, Edward ^{[1
]}

Han, Zehua ^{[1
]}

Hemmer, Philip ^{[1
]}

Kattawar, George ^{[1
]}

Kim, Moochan ^{[1
]}

Lee, Ming-Che ^{[1
]}

Lu, Chaoyang ^{[2
]}

Mogford, Jon ^{[1
]}

Nessler, Reed ^{[1
]}

Neuman, Ben ^{[1
]}

Nie, Xiaoyu ^{[1
,5
]}

Pan, Jianwei ^{[2
]}

Pryor, Jane ^{[1
]}

Rajil, Navid ^{[1
]}

Shih, Yanhua ^{[6
]}

Sokolov, Alexei ^{[1
]}

Svidzinsky, Anatoly ^{[1
]}

Wang, Dawei ^{[7
]}

Yi, Zhenhuan ^{[1
]}

Zheltikov, Aleksei ^{[1
,8
]}

Scully, Marlan ^{[1
,9
,10
]}

机构：

[1] Texas A&M Univ, College Stn, TX 77843 USA

[2] Univ Sci & Technol China, Hefei 230026, Peoples R China

[3] Leibniz Inst Photon Technol, D-07745 Jena, Germany

[4] Friedrich Schiller Univ Jena, Helmholtzweg 4, D-07743 Jena, Germany

[5] Xi An Jiao Tong Univ, Xian 710049, Shaanxi, Peoples R China

[6] Univ Maryland Baltimore Cty, Baltimore, MD 21250 USA

[7] Zhejiang Univ, Hangzhou 310027, Peoples R China

[8] Moscow MV Lomonosov State Univ, Moscow 119992, Russia

[9] Baylor Univ, Waco, TX 76798 USA

[10] Princeton Univ, Princeton, NJ 08544 USA

来源：

APPLIED PHYSICS LETTERS | 2020年 / 117卷 / 12期

基金：

美国国家科学基金会;

关键词：

GOLD NANOPARTICLES;

D O I：

10.1063/5.0021842

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Lateral flow assay (LFA) has long been used as a biomarker detection technique. It has advantages such as low cost, rapid readout, portability, and ease of use. However, its qualitative readout process and lack of sensitivity are limiting factors. We report a photon-counting approach to accurately quantify LFAs while enhancing sensitivity. In particular, we demonstrate that the density of SARS-CoV-2 antibodies can be quantified and measured with an enhanced sensitivity using this simple laser optical analysis.

引用

页数：4

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