Original Nerve Growth Factor Mimetic Dipeptide GK-2 Limits the Manifestations of Hemorrhagic Stroke in Rats

被引：2
|
作者：
Kraineva, V. A. [1 ]
Gudasheva, T. A. [1 ]
Kotelnikova, S. O. [1 ]
Antipova, T. A. [1 ]
Seredenin, S. B. [1 ]
机构：
[1] Russian Acad Med Sci, VV Zakusov Inst Pharmacol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2013年 / 154卷 / 05期
关键词：
nerve growth factor low-molecular mimetic; nerve growth factor; dipeptide; hemorrhagic stroke; ISCHEMIA;
D O I：
10.1007/s10517-013-2020-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The protective effects of a new low-molecular-weight mimetic of nerve growth factor hexamethylene diamide bis-(N-monosuccinyl-L-glutamine-L-lysine; GK-2) were studied on the experimental model of hemorrhagic stroke (intracerebral posttraumatic hematoma) in rats. Intraperitoneal injections of GK-2 in a dose of 1 mg/kg 4 and 24 h after surgery and 24 h before testing the CNS function on days 3, 7, and 14 prevent death of experimental animals, reduce the neurological deficit, and normalized behavior.
引用
收藏
页码：642 / 644
页数：3
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