Antitumor effect of poly(ethylene glycol)modified fullerene

被引：49
|
作者：
Tabata, Y [1 ]
Murakami, Y [1 ]
Ikada, Y [1 ]
机构：
[1] KYOTO UNIV,BIOMED ENGN RES CTR,SAKYO KU,KYOTO 606,JAPAN
来源：
FULLERENE SCIENCE AND TECHNOLOGY | 1997年 / 5卷 / 05期
关键词：
D O I：
10.1080/15363839708013312
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Water-insoluble fullerene (C-60) was chemically modified with poly(ethylene glycol) (PEG) to solubilize it in water. The C-60-PEG conjugates, upon injecting intravenously, were accumulated in the tumor to a greater extent than in the normal tissue and exhibited prolonged C-60 retention at the tumor tissue. Conjugate injection followed by light irradiation significantly suppressed the volume increase of tumor. We conclude that the PEG-modified C-60 has a high potentiality as a drug of photodynamic tumor therapy.
引用
收藏
页码：989 / 1007
页数：19
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