Synthesis, antibacterial and antifungal activity of some new thiazolylhydrazone derivatives containing 3-substituted cyclobutane ring

被引：170

作者：

Cukurovali, A ^{[1
]}

Yilmaz, I

Gur, S

Kazaz, C

机构：

[1] Firat Univ, Fac Arts & Sci, Dept Chem, TR-23119 Elazig, Turkey

[2] Firat Univ, Fac Arts & Sci, Dept Biol, TR-23119 Elazig, Turkey

[3] Ataturk Univ, Fac Arts & Sci, Dept Chem, TR-25240 Erzurum, Turkey

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 02期

关键词：

cyclobutane; thiosemicarbazone; antibacterial activity; antifungal activity; MIC;

D O I：

10.1016/j.ejmech.2005.01.013

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of Schiff bases, combining 2,4-disubstituted thiazole and cyclobutane rings, and hydrazone moieties in the same molecule, was synthesized, characterized and evaluated for screening antibacterial and antifungal activities on microorganisms, respectively, on four bacteria and Candida tropicalis. The structures of original compounds were confirmed by analytical and spectroscopic (FT-IR, H-1 NMR and C-13 NMR) methods and elemental analysis. Both the antibacterial and antifungal activities and MIC values of compounds were reported. Among the tested compounds, the most effective compound providing a MIC value of 16 mu g ml(-1) are 2 against C. tropicalis and Bacillus subtilis and 3 against B. subtilis only. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：201 / 207

页数：7

共 50 条

[1] Synthesis and antifungal activity of some thiazolylhydrazone derivatives
Ozdemir, Ahmet
Turan-Zitouni, Gulhan
Kaplancikli, Zafer Asim
Demirci, Fatih
Iscan, Gokalp
[J]. DRUGS OF THE FUTURE, 2007, 32 : 125 - 125
[2] Synthesis and in vitro antifungal activities of new 3-substituted benzopyrone derivatives
Lv, Zhiliang
Sheng, Chunquan
Zhang, Yikai
Wang, Tiantian
Feng, Jilu
Sun, Hailing
Zhong, Hanyu
Zhang, Mingfeng
Chen, Huan
Li, Ke
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (23) : 7106 - 7109
[3] Synthesis and antifungal activity of 3-substituted thiochromanones
Liu, Yang
Luo, Wei
Sun, Li
Guo, Chun
[J]. DRUG DISCOVERIES AND THERAPEUTICS, 2008, 2 (04): : 216 - 218
[4] Synthesis and antinociceptive activity of some 3-substituted benzothiazolone derivatives
Çakir, B
Ulucay, A
Dogruer, DS
Isimer, A
Sahin, MF
[J]. FARMACO, 1999, 54 (11-12): : 846 - 851
[5] Synthesis and antifungal activities of 3-substituted phthalide derivatives
Fan, Lingling
Luo, Bilan
Luo, Zhongfu
Zhang, Li
Fan, Judi
Xue, Wei
Tang, Lei
Li, Yong
[J]. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2019, 74 (11-12): : 811 - 818
[6] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME 2-AND 3-SUBSTITUTED ISOQUINOLINONES
Roopan, S. Mohana
Sri, T. R. Sakthi
Reddy, B. Ramakrishna
Khan, F. Nawaz
[J]. INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2009, 19 (01) : 77 - 78
[7] SYNTHESIS AND PROPERTIES OF SOME NEW 3-SUBSTITUTED HEXESTROL DERIVATIVES
VILKAS, M
MASAMBA, L
MAKANI, S
LECLERCQ, G
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1987, 22 (01) : 27 - 31
[8] SYNTHESIS AND STUDIES OF SOME NEW 3-SUBSTITUTED COUMARIN DERIVATIVES
IBRAHIM, TM
AHMED, FSM
SHEDID, SA
[J]. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1994, 86 (1-4): : 263 - 268
[9] Design, synthesis, antibacterial, and antifungal studies of novel 3-substituted coumarinyl-triazine derivatives
Modh, Rahul P.
Patel, Amit C.
Chikhalia, Kishor H.
[J]. HETEROCYCLIC COMMUNICATIONS, 2013, 19 (05) : 343 - 349
[10] Synthesis, structure and antibacterial activity of 3-substituted derivatives of 4-hydroxycoumarin
Zavrsnik, Davorka
Spirtovic-Halilovic, Selma
Softic, Dzenita
[J]. PERIODICUM BIOLOGORUM, 2011, 113 (01) : 93 - 97

← 1 2 3 4 5 →