In this paper, the method named subsequence analysis is introduced to study the global asymptotic stability of the following two families of difference equations: x(n) = x(n-k)x(n-l) + a/x(n-k) + x(n-l), n = 1, 2, ..., and x(n) = x(n-k) + x(n-l)/1 + ax(n-k)x(n-l), n = 1, 2, ..., where k and l are integers, 1 <= k <= l, a > 0, x(0), x(-1), ..., x(-(l-1)) is an element of (0,8). This method is novel and can be used to simplify the proof of similar kinds of stability problems with complicated semi-cycle structure.