Kinetic resolution of racemic α-hydroxyphosphonates by asymmetric esterification using achiral carboxylic acids with pivalic anhydride and a chiral acyl-transfer catalyst

被引：26

作者：

Shiina, Isamu ^{[1
]}

Ono, Keisuke ^{[1
]}

Nakahara, Takayoshi ^{[1
]}

机构：

[1] Tokyo Univ Sci, Fac Sci, Dept Appl Chem, Shinjuku Ku, Tokyo 1628601, Japan

来源：

CHEMICAL COMMUNICATIONS | 2013年 / 49卷 / 91期

关键词：

ALCOHOLS; INHIBITORS; HYDROXYALKANEPHOSPHONATES; ANALOGS; PHOSPHONATES;

D O I：

10.1039/c3cc44293d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A practical protocol is developed to directly provide chiral alpha-acyloxyphosphonates and alpha-hydroxyphosphonates from (+/-)-alpha-hydroxyphosphonates utilizing the transacylation process to generate the mixed anhydrides from acid components and pivalic anhydride in the presence of organocatalysts (s-value = 33-518).

引用

页码：10700 / 10702

页数：3

共 48 条

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