Telomere shortening in peripheral blood cells was related with aging but not with white blood cell count

被引：24
|
作者：
Satoh, H [1 ]
Hiyama, K [1 ]
Takeda, M [1 ]
Awaya, Y [1 ]
Watanabe, K [1 ]
Ihara, Y [1 ]
Maeda, H [1 ]
Ishioka, S [1 ]
Yamakido, M [1 ]
机构：
[1] HIROSHIMA UNIV,SCH MED,DEPT INTERNAL MED 2,MINAMI KU,HIROSHIMA 734,JAPAN
来源：
JAPANESE JOURNAL OF HUMAN GENETICS | 1996年 / 41卷 / 04期
关键词：
telomere; blood cell; aging; cell division; white blood cell count;
D O I：
10.1007/BF01876332
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Telomeres in somatic cells are progressively shortened with aging. We investigated the relationship between the telomere length and other factors which may affect the frequency of cell divisions, in peripheral blood cells. Shortening of telomeric repeats was correlated with aging (p<0.0001), but not with white blood cell count, neutrophil count, and smoking habit. Not only the number of cell divisions, but also some other factors, such as upregulation level of telomerase activity concomitant with the cell division in hematopoietic progenitor cells, might affect the length of telomeric repeats in blood cells.
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页码：413 / 417
页数：5
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