Telomere shortening in peripheral blood cells was related with aging but not with white blood cell count

被引：24

作者：

Satoh, H ^{[1
]}

Hiyama, K ^{[1
]}

Takeda, M ^{[1
]}

Awaya, Y ^{[1
]}

Watanabe, K ^{[1
]}

Ihara, Y ^{[1
]}

Maeda, H ^{[1
]}

Ishioka, S ^{[1
]}

Yamakido, M ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH MED,DEPT INTERNAL MED 2,MINAMI KU,HIROSHIMA 734,JAPAN

来源：

JAPANESE JOURNAL OF HUMAN GENETICS | 1996年 / 41卷 / 04期

关键词：

telomere; blood cell; aging; cell division; white blood cell count;

D O I：

10.1007/BF01876332

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Telomeres in somatic cells are progressively shortened with aging. We investigated the relationship between the telomere length and other factors which may affect the frequency of cell divisions, in peripheral blood cells. Shortening of telomeric repeats was correlated with aging (p<0.0001), but not with white blood cell count, neutrophil count, and smoking habit. Not only the number of cell divisions, but also some other factors, such as upregulation level of telomerase activity concomitant with the cell division in hematopoietic progenitor cells, might affect the length of telomeric repeats in blood cells.

引用

下载

页码：413 / 417

页数：5

共 50 条

[1] Telomere shortening in peripheral blood neutrophils and T cells with age in healthy individuals
Robertson, JD
Gale, R
Wynn, RF
Robinson, SA
Greaves, MJ
Dougal, M
Linch, DC
Boyle, J
Testa, NG
Chopra, R
BRITISH JOURNAL OF HAEMATOLOGY, 1999, 105 : 103 - 103
[2] Peripheral white blood cell count as a screening tool for ventriculostomy-related infections
Nisson, Peyton L.
James, Whitney S.
Gaub, Michael B.
Borgstrom, Mark
Weinand, Martin
Anton, Rein
JOURNAL OF CLINICAL NEUROSCIENCE, 2019, 67 : 52 - 58
[3] Polycystic ovary syndrome and the peripheral blood white cell count
Herlihy, A. C.
Kelly, R. E.
Hogan, J. L.
O'Connor, N.
Farah, N.
Turner, M. J.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2011, 31 (03) : 242 - 244
[4] Combined peripheral blood monocyte count and white blood cell count as a guide for successful one-day autologous peripheral blood stem cell collection
Watanaboonyongcharoen, Phandee
Lorucharoen, Nattarat
Wudhikarn, Kitsada
Bunworasate, Udomsak
Chanswangphuwana, Chantiya
Rojnuckarin, Ponlapat
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY, 2024,
[5] WHITE BLOOD CELL COUNT
临床检验杂志, 1986, (04) : 220 - 221
[6] The white blood cell count
不详
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1933, 101 : 1240 - 1240
[7] The white blood cell count
Sever, JW
JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1933, 101 : 1899 - 1899
[8] Trapping cells in paper for white blood cell count
Zhang, Yi
Bai, Jianhao
Wu, Hong
Ying, Jackie Y.
BIOSENSORS & BIOELECTRONICS, 2015, 69 : 121 - 127
[9] Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders
Obana, N
Takagi, S
Kinouchi, Y
Tokita, Y
Sekikawa, A
Takahashi, S
Hiwatashi, N
Oikawa, S
Shimosegawa, T
INTERNAL MEDICINE, 2003, 42 (02) : 150 - 153
[10] Aging and Changes in White Blood Cells Count and Immunity: A Systematic Review
Abukanna, Abdelrahman Mohamed Ahmed
AlAnazi, Fatimah Mofareh
AlAnazi, Zainab Mofareh
AlAnazi, Feryal Ayed L.
AlAnaz, Afnan Hamdan Owayn
AlAnazi, Rahaf Meshal L.
CLINICAL CANCER INVESTIGATION JOURNAL, 2022, 11 (06): : 25 - 30

← 1 2 3 4 5 →