Regulation of expression of microRNAs by DNA methylation in lung cancer

被引：10
|
作者：
Singh, Dhirendra Kumar [1 ]
Bose, Sudeep [1 ]
Kumar, Sachin [2 ]
机构：
[1] Amity Univ, Amity Inst Biotechnol, Noida, Uttar Pradesh, India
[2] Amity Univ, Amity Inst Mol Med & Stem Cell Res, Noida, Uttar Pradesh, India
来源：
BIOMARKERS | 2016年 / 21卷 / 07期
关键词：
Angiogenesis; biomarker; DNA hypermethylation; microRNA expression; survival; TUMOR-SUPPRESSOR GENES; NONSMALL CELL; CLINICAL-SIGNIFICANCE; MIRNA EXPRESSION; PROMOTER HYPERMETHYLATION; EPIGENETIC INACTIVATION; PANCREATIC-CANCER; GASTRIC-CANCER; STEM-CELLS; METASTASIS;
D O I：
10.3109/1354750X.2016.1171906
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Differential expression of miRNAs has been linked with lung carcinogenesis. Recent studies have indicated that DNA hypermethylation can lead to silencing of tumor suppressor miRNA-encoding genes. Restoration of tumor suppressor miRNAs using inhibitors of DNA methyltransferases has been shown to suppress cell proliferation, angiogenesis, invasion and metastasis implying that modulation of methylation of specific miRNAs can be used as novel therapeutic targets in lung cancer. In this review, we highlight tremendous progress which has been made in the identification of methylation-mediated silencing of miRNAs and their contribution in lung carcinogenesis along with the clinical utility of methylated miRNAs.
引用
收藏
页码：589 / 599
页数：11
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