Polyamine metabolism in rat myocardial ischemia-reperfusion injury

被引：17
|
作者：
Han, Liping [1 ,2 ]
Xu, Changqing [1 ,3 ]
Guo, Yimin [2 ]
Li, Hongzhu [1 ]
Jiang, Chunming [1 ]
Zhao, Yajun [1 ]
机构：
[1] Harbin Med Coll, Dept Pathophysiol, Harbin 150086, Peoples R China
[2] Wenzhou Med Coll, Dept Physiol, Wenzhou 325035, Peoples R China
[3] Biopharmaceut Key Lab Heilongjiang Prov, Harbin 150086, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CARDIOLOGY | 2009年 / 132卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Ischemia; Reperfusion; Heart; Polyamines; ODC; SSAT; OVEREXPRESSION; CELLS;
D O I：
10.1016/j.ijcard.2007.07.163
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study was focused on investigating the involvement of polyamine metabolism in the myocardial ischemia-reperfusion injury (MIRI) in an in vivo rat model. A branch of the descending left coronary artery was occluded for 30 min followed by 2 h, 6 h, 12 h, and 24 h reperfusion. Then the expression of spermidine/spermine N1-acetyltransferase (SSAT) and ornithine decarboxylase (ODC) and the concentrations of polyamines were assessed. It was found that the expression of SSAT and ODC were upregulated after reperfusion and the concentrations of spermidine and spermine were significantly decreased, while putrescine concentration was significantly increased. The results suggest that MIRI may cause disturbance of polyamine metabolism, and it may play a critical role in MIRI. (c) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：142 / 144
页数：4
相关论文
共 50 条
  • [41] ISCHEMIA-REPERFUSION INJURY IN ISOLATED RAT HINDQUARTERS
    SEXTON, WL
    KORTHUIS, RJ
    LAUGHLIN, MH
    JOURNAL OF APPLIED PHYSIOLOGY, 1990, 68 (01) : 387 - 392
  • [42] Myocardial ischemia-reperfusion injury; Molecular mechanisms and prevention
    Liu, Yang
    Li, Lei
    Wang, Zhen
    Zhang, Juan
    Zhou, Zhou
    MICROVASCULAR RESEARCH, 2023, 149
  • [43] CORONARY MICROVASCULAR INJURY FROM MYOCARDIAL ISCHEMIA-REPERFUSION
    MCDONAGH, PF
    INTERNATIONAL JOURNAL OF MICROCIRCULATION-CLINICAL AND EXPERIMENTAL, 1984, 3 (3-4): : 441 - 441
  • [44] Effect of trapidil in myocardial ischemia-reperfusion injury in rabbit
    Liu, MingJie
    Sun, Qi
    Wang, Qiang
    Wang, Xiuying
    Lin, Peng
    Yang, Ming
    Yan, Yuanyuan
    INDIAN JOURNAL OF PHARMACOLOGY, 2014, 46 (02) : 207 - 210
  • [45] Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury
    Toldo, Stefano
    Mauro, Adolfo G.
    Cutter, Zachary
    Abbate, Antonio
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2018, 315 (06): : H1553 - H1568
  • [46] Mitochondrial redox regulation and myocardial ischemia-reperfusion injury
    Chen, Chwen-Lih
    Zhang, Liwen
    Jin, Zhicheng
    Kasumov, Takhar
    Chen, Yeong-Renn
    AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022, 322 (01): : C12 - C23
  • [47] Myocardial ischemia-reperfusion injury: a neglected therapeutic target
    Hausenloy, Derek J.
    Yellon, Derek M.
    JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (01): : 92 - 100
  • [48] Mechanisms and therapeutic advances of myocardial ischemia-reperfusion injury
    张萌
    高山
    李丹阳
    饶宏宇
    South China Journal of Cardiology, 2022, 23 (01) : 14 - 18
  • [49] HIF-1α in myocardial ischemia-reperfusion injury
    Zheng, Jie
    Chen, Peier
    Zhong, Jianfeng
    Cheng, Yu
    Chen, Hao
    He, Yuan
    Chen, Can
    MOLECULAR MEDICINE REPORTS, 2021, 23 (05)
  • [50] The role of natural IgM in myocardial ischemia-reperfusion injury
    Zhang, Ming
    Michael, Lloyd H.
    Grosjean, Sandrine A.
    Kelly, Ralph A.
    Carroll, Michael C.
    Entman, Mark L.
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2006, 41 (01) : 62 - 67
12345